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IL17RE interleukin 17 receptor E [ Homo sapiens (human) ]

Gene ID: 132014, updated on 12-Oct-2019

Summary

Official Symbol
IL17REprovided by HGNC
Official Full Name
interleukin 17 receptor Eprovided by HGNC
Primary source
HGNC:HGNC:18439
See related
Ensembl:ENSG00000163701 MIM:614995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Expression
Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues See more
Orthologs

Genomic context

See IL17RE in Genome Data Viewer
Location:
3p25.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9902087..9916402)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9944296..9958086)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene jagunal homolog 1 Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene interleukin 17 receptor C Neighboring gene cysteine rich with EGF like domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
    IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL-17 signaling pathway, conserved biosystem (from KEGG)
    IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
  • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-17 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-17 signaling, organism-specific biosystemInterleukin-17 (IL17) is a family of cytokines (Kawaguchi et al. 2004, Gu et al. 2013). IL17A, the founding member of the family, member of this family, is able to induce the production of other cyt...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23658, MGC71884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
interleukin-17-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-17 receptor E
Names
IL-17 receptor E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193380.2NP_001180309.1  interleukin-17 receptor E isoform 6 precursor

    See identical proteins and their annotated locations for NP_001180309.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 6, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018809, AF458069, AK074238, AK096801, AK297697
    Consensus CDS
    CCDS54552.1
    UniProtKB/Swiss-Prot
    Q8NFR9
    UniProtKB/TrEMBL
    B4DMZ3
    Related
    ENSP00000388086.2, ENST00000454190.6
    Conserved Domains (1) summary
    pfam15037
    Location:75433
    IL17_R_N; Interleukin-17 receptor extracellular region
  2. NM_153480.2NP_705613.1  interleukin-17 receptor E isoform 1 precursor

    See identical proteins and their annotated locations for NP_705613.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AF458069, AK074238, BC137077
    Consensus CDS
    CCDS2589.1
    UniProtKB/Swiss-Prot
    Q8NFR9
    Related
    ENSP00000373325.3, ENST00000383814.8
    Conserved Domains (2) summary
    pfam15037
    Location:75448
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:488611
    TIR_2; TIR domain
  3. NM_153481.2NP_705614.1  interleukin-17 receptor E isoform 2

    See identical proteins and their annotated locations for NP_705614.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK074238, AK096801, BC137077
    UniProtKB/Swiss-Prot
    Q8NFR9
    Conserved Domains (2) summary
    pfam15037
    Location:1332
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:372495
    TIR_2; TIR domain
  4. NM_153483.2NP_705616.2  interleukin-17 receptor E isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK074238, BC137077, DA592287
    UniProtKB/Swiss-Prot
    Q8NFR9
    Related
    ENSP00000404916.1, ENST00000421412.5
    Conserved Domains (2) summary
    pfam15037
    Location:115488
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:528651
    TIR_2; TIR domain

RNA

  1. NR_104198.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF458069, AK096793
    Related
    ENST00000383815.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    9902087..9916402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533361.3XP_011531663.1  interleukin-17 receptor E isoform X1

    Conserved Domains (2) summary
    pfam15037
    Location:98454
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:494617
    TIR_2; TIR domain
  2. XM_006712976.1XP_006713039.1  interleukin-17 receptor E isoform X4

    See identical proteins and their annotated locations for XP_006713039.1

    UniProtKB/Swiss-Prot
    Q8NFR9
    Conserved Domains (2) summary
    pfam15037
    Location:1332
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:372495
    TIR_2; TIR domain
  3. XM_006712975.1XP_006713038.1  interleukin-17 receptor E isoform X2

    See identical proteins and their annotated locations for XP_006713038.1

    Conserved Domains (2) summary
    pfam15037
    Location:52408
    IL17_R_N; Interleukin-17 receptor extracellular region
    cl23749
    Location:448571
    TIR_2; TIR domain
  4. XM_011533362.2XP_011531664.1  interleukin-17 receptor E isoform X5

    Conserved Domains (1) summary
    pfam15037
    Location:75366
    IL17_R_N; Interleukin-17 receptor extracellular region
  5. XM_024453350.1XP_024309118.1  interleukin-17 receptor E isoform X3

    Conserved Domains (1) summary
    pfam15037
    Location:79432
    IL17_R_N; Interleukin-17 receptor extracellular region
  6. XM_011533364.2XP_011531666.1  interleukin-17 receptor E isoform X7

    Conserved Domains (1) summary
    pfam15037
    Location:75366
    IL17_R_N; Interleukin-17 receptor extracellular region
  7. XM_011533363.2XP_011531665.1  interleukin-17 receptor E isoform X6

    Conserved Domains (1) summary
    pfam15037
    Location:75409
    IL17_R_N; Interleukin-17 receptor extracellular region

RNA

  1. XR_940380.1 RNA Sequence

  2. XR_940381.1 RNA Sequence

  3. XR_940382.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144640.2: Suppressed sequence

    Description
    NM_144640.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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