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TAMM41 TAM41 mitochondrial translocator assembly and maintenance homolog [ Homo sapiens (human) ]

Gene ID: 132001, updated on 17-Jun-2019

Summary

Official Symbol
TAMM41provided by HGNC
Official Full Name
TAM41 mitochondrial translocator assembly and maintenance homologprovided by HGNC
Primary source
HGNC:HGNC:25187
See related
Ensembl:ENSG00000144559 MIM:614948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAM41; TAM41; C3orf31
Expression
Ubiquitous expression in ovary (RPKM 1.6), lymph node (RPKM 1.4) and 25 other tissues See more
Orthologs

Genomic context

See TAMM41 in Genome Data Viewer
Location:
3p25.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (11721896..11846919, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11831916..11888393, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC105376952 Neighboring gene vestigial like family member 4 Neighboring gene FANCD2 pseudogene 2 Neighboring gene CYCS pseudogene 12 Neighboring gene nucleoporin 210 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14209, MGC16471, DKFZp434E0519

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cardiolipin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
extrinsic component of mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
phosphatidate cytidylyltransferase, mitochondrial
Names
CDP-DAG synthase
CDP-diacylglycerol synthase
MMP37-like protein, mitochondrial
TAM41, mitochondrial translocator assembly and maintenance protein, homolog
mitochondrial translocator assembly and maintenance protein 41 homolog
NP_001271330.1
NP_001308223.1
NP_001308224.1
NP_001352960.1
NP_620162.1
XP_005264930.1
XP_005264932.1
XP_016861214.1
XP_016861215.1
XP_016861216.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284401.2NP_001271330.1  phosphatidate cytidylyltransferase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001271330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK092776, AL561371, AL561480, BC015088, BM678701, DB475191
    Consensus CDS
    CCDS68345.1
    UniProtKB/Swiss-Prot
    Q96BW9
    Related
    ENSP00000398596.1, ENST00000455809.5
    Conserved Domains (1) summary
    pfam09139
    Location:13327
    Mmp37; Mitochondrial matrix Mmp37
  2. NM_001321294.2NP_001308223.1  phosphatidate cytidylyltransferase, mitochondrial isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an additional exon, and it thus differs in its 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct and shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC090958, AK092776, AL561371, AL561480, BC015088, BM678701, DB155729, DB475191
    UniProtKB/Swiss-Prot
    Q96BW9
    Conserved Domains (1) summary
    pfam09139
    Location:5286
    Mmp37; Mitochondrial matrix Mmp37
  3. NM_001321295.2NP_001308224.1  phosphatidate cytidylyltransferase, mitochondrial isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains two additional exons, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC090958, AK092776, AL561371, AL561480, BC015088, BM678701, BM821725, DB155729, DB475191
    UniProtKB/Swiss-Prot
    Q96BW9
    Conserved Domains (1) summary
    pfam09139
    Location:1161
    Mmp37; Mitochondrial matrix Mmp37
  4. NM_001366031.2NP_001352960.1  phosphatidate cytidylyltransferase, mitochondrial isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC090958
    Conserved Domains (1) summary
    pfam09139
    Location:13236
    Mmp37; Mitochondrial matrix Mmp37
  5. NM_138807.4NP_620162.1  phosphatidate cytidylyltransferase, mitochondrial isoform b precursor

    See identical proteins and their annotated locations for NP_620162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BC015088, BM678701, DB475191
    Consensus CDS
    CCDS2607.1
    UniProtKB/Swiss-Prot
    Q96BW9
    Related
    ENSP00000273037.5, ENST00000273037.9
    Conserved Domains (1) summary
    pfam09139
    Location:13303
    Mmp37; Mitochondrial matrix Mmp37

RNA

  1. NR_104314.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes two additional internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK092776, BC015088, BM678701, DB475191
    Related
    ENST00000457498.5
  2. NR_135609.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains three additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090939, AC090958, AK092776, AK303598, AL561371, AL561480, BC015088, BM678701, BM821725, DB155729, DB475191
  3. NR_135610.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains two additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090939, AC090958, AK092776, AL561371, AL561480, BC015088, BM678701, BM821725, DB155729, DB475191
  4. NR_135611.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an additional exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC090939, AK092776, AL561371, AL561480, BC015088, BM678701, DB475191
  5. NR_158710.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090939, AC090958
  6. NR_158711.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090939, AC090958
  7. NR_158712.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090939, AC090958
  8. NR_158713.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090958
  9. NR_158714.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090939, AC090958
  10. NR_158715.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC090958

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    11721896..11846919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005725.2XP_016861214.1  phosphatidate cytidylyltransferase, mitochondrial isoform X2

  2. XM_017005727.1XP_016861216.1  phosphatidate cytidylyltransferase, mitochondrial isoform X4

  3. XM_005264873.4XP_005264930.1  phosphatidate cytidylyltransferase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005264930.1

    UniProtKB/Swiss-Prot
    Q96BW9
    Related
    ENSP00000388598.2, ENST00000444133.6
    Conserved Domains (1) summary
    pfam09139
    Location:13316
    Mmp37; Mitochondrial matrix Mmp37
  4. XM_005264875.4XP_005264932.1  phosphatidate cytidylyltransferase, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam09139
    Location:13187
    Mmp37; Mitochondrial matrix Mmp37
  5. XM_017005726.2XP_016861215.1  phosphatidate cytidylyltransferase, mitochondrial isoform X3

RNA

  1. XR_001740020.2 RNA Sequence

  2. XR_001740021.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871060.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    141500..172144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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