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Gadd45a growth arrest and DNA-damage-inducible 45 alpha [ Mus musculus (house mouse) ]

Gene ID: 13197, updated on 1-Mar-2024

Summary

Official Symbol
Gadd45aprovided by MGI
Official Full Name
growth arrest and DNA-damage-inducible 45 alphaprovided by MGI
Primary source
MGI:MGI:107799
See related
Ensembl:ENSMUSG00000036390 AllianceGenome:MGI:107799
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddit1; GADD45
Summary
Enables promoter-specific chromatin binding activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and negative regulation of peptidyl-serine phosphorylation of STAT protein. Acts upstream of or within centrosome cycle; negative regulation of protein kinase activity; and regulation of cell cycle. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; sensory organ; and tibialis anterior. Used to study systemic lupus erythematosus. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 73.1), liver E14 (RPKM 52.4) and 24 other tissues See more
Orthologs
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Genomic context

See Gadd45a in Genome Data Viewer
Location:
6 C1; 6 30.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67012080..67014391, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67035096..67037407, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 12 Neighboring gene STARR-seq mESC enhancer starr_16163 Neighboring gene STARR-seq mESC enhancer starr_16164 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene RIKEN cDNA E230016M11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:66987352-66987653 Neighboring gene predicted gene, 53333 Neighboring gene predicted gene, 25260 Neighboring gene STARR-seq mESC enhancer starr_16168 Neighboring gene predicted gene, 29928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:67078989-67079098 Neighboring gene STARR-seq mESC enhancer starr_16169 Neighboring gene RIKEN cDNA A430010J10 gene Neighboring gene STARR-positive B cell enhancer ABC_E2786

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centrosome cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
growth arrest and DNA damage-inducible protein GADD45 alpha
Names
DDIT-1
DNA damage-inducible transcript 1 protein
DNA-damage-inducible transcript 1
Gadd45alpha
growth arrest and DNA-damage-inducible, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007836.1NP_031862.1  growth arrest and DNA damage-inducible protein GADD45 alpha

    See identical proteins and their annotated locations for NP_031862.1

    Status: VALIDATED

    Source sequence(s)
    L28177
    Consensus CDS
    CCDS20217.1
    UniProtKB/Swiss-Prot
    P48316
    UniProtKB/TrEMBL
    Q3UMH6
    Related
    ENSMUSP00000044034.7, ENSMUST00000043098.9
    Conserved Domains (1) summary
    pfam01248
    Location:21105
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    67012080..67014391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)