U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GRK7 G protein-coupled receptor kinase 7 [ Homo sapiens (human) ]

Gene ID: 131890, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GRK7provided by HGNC
Official Full Name
G protein-coupled receptor kinase 7provided by HGNC
Primary source
HGNC:HGNC:17031
See related
Ensembl:ENSG00000114124 MIM:606987; AllianceGenome:HGNC:17031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRK7
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GRK7 in Genome Data Viewer
Location:
3q23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141749984..141819352)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144510619..144566648)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141482250..141538194)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2618 Neighboring gene TPT1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141456933-141457612 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141457613-141458291 Neighboring gene ring finger protein 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:141481495-141481669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20638 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4237 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4238 Neighboring gene uncharacterized LOC105374134 Neighboring gene VISTA enhancer hs2041 Neighboring gene Sharpr-MPRA regulatory region 4874 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 25

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cone deactivation kinetics and GRK1/GRK7 expression in enhanced S cone syndrome caused by mutations in NR2E3. Cideciyan AV, et al. Invest Ophthalmol Vis Sci, 2003 Mar. PMID 12601058
  2. A tale of two kinases in rods and cones. Osawa S, et al. Adv Exp Med Biol, 2012. PMID 22183412, Free PMC Article
  3. Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases. Dzimiri N, et al. Eur J Pharmacol, 2004 Apr 12. PMID 15087239
  4. Characterization of human GRK7 as a potential cone opsin kinase. Chen CK, et al. Mol Vis, 2001 Dec 21. PMID 11754336
  5. Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. Torisawa A, et al. Photochem Photobiol, 2008 Jul-Aug. PMID 18266817

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation.
    Title: A tale of two kinases in rods and cones.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. synthesis of 29 of GRK1 or GRK7 partial peptides that cover the entire sequence of GRK1/GRK7, to see which interacts with recoverin.
    Title: Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin.
  6. Phosphorylation of GRK1 and GRK7 by PKA occurs in the dark, when cAMP levels in photoreceptor cells are elevated.
    Title: Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rhodopsin kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rhodopsin kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rhodopsin kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rhodopsin kinase GRK7
Names
g protein-coupled receptor kinase GRK7
NP_631948.1
XP_047303405.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139209.3 → NP_631948.1  rhodopsin kinase GRK7

    See identical proteins and their annotated locations for NP_631948.1

    Status: REVIEWED

    Source sequence(s)
    AC112504
    Consensus CDS
    CCDS3120.1
    UniProtKB/Swiss-Prot
    Q8WTQ7
    Related
    ENSP00000508022.1, ENST00000682958.1
    Conserved Domains (2) summary
    cd08749
    Location:40 → 181
    RGS_GRK7; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
    cd05607
    Location:188 → 474
    STKc_GRK7; Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    141749984..141819352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447449.1 → XP_047303405.1  rhodopsin kinase GRK7 isoform X1

    UniProtKB/Swiss-Prot
    Q8WTQ7
    Related
    ENSP00000264952.2, ENST00000264952.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    144510619..144566648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WTQ7.1 GenPept UniProtKB/Swiss-Prot:Q8WTQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous