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GRK7 G protein-coupled receptor kinase 7 [ Homo sapiens (human) ]

Gene ID: 131890, updated on 5-Jan-2022

Summary

Official Symbol
GRK7provided by HGNC
Official Full Name
G protein-coupled receptor kinase 7provided by HGNC
Primary source
HGNC:HGNC:17031
See related
Ensembl:ENSG00000114124 MIM:606987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPRK7
Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GRK7 in Genome Data Viewer
Location:
3q23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141763408..141819352)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141482250..141538194)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2618 Neighboring gene TPT1 pseudogene 3 Neighboring gene ring finger protein 7 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4237 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4238

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables rhodopsin kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables rhodopsin kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables rhodopsin kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of rhodopsin mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in photoreceptor disc membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rhodopsin kinase GRK7
Names
g protein-coupled receptor kinase GRK7
NP_631948.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139209.3NP_631948.1  rhodopsin kinase GRK7

    See identical proteins and their annotated locations for NP_631948.1

    Status: REVIEWED

    Source sequence(s)
    AC112504
    Consensus CDS
    CCDS3120.1
    UniProtKB/Swiss-Prot
    Q8WTQ7
    Related
    ENSP00000508022.1, ENST00000682958.1
    Conserved Domains (2) summary
    cd08749
    Location:40181
    RGS_GRK7; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 7 (GRK7)
    cd05607
    Location:188474
    STKc_GRK7; Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    141763408..141819352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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