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Dcc deleted in colorectal carcinoma [ Mus musculus (house mouse) ]

Gene ID: 13176, updated on 10-Jan-2023

Summary

Official Symbol
Dccprovided by MGI
Official Full Name
deleted in colorectal carcinomaprovided by MGI
Primary source
MGI:MGI:94869
See related
Ensembl:ENSMUSG00000060534 AllianceGenome:MGI:94869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igdcc1; C030036D22Rik
Summary
Predicted to enable identical protein binding activity; netrin receptor activity; and transcription coactivator activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within generation of neurons. Located in axon. Is integral component of postsynaptic density membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 7.6), CNS E14 (RPKM 7.4) and 5 other tissues See more
Orthologs
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Genomic context

See Dcc in Genome Data Viewer
Location:
18 E2; 18 45.24 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (71386703..72484299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (71253613..72351228, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated protein transmembrane 4B pseudogene Neighboring gene ribosomal protein S6 kinase, polypeptide 1 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene predicted gene, 31819

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables netrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord ventral commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in growth cone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
netrin receptor DCC
Names
tumor suppressor protein DCC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007831.3NP_031857.2  netrin receptor DCC precursor

    See identical proteins and their annotated locations for NP_031857.2

    Status: VALIDATED

    Source sequence(s)
    AC136637, AK090377, AK157715, BQ550935, CN665025
    Consensus CDS
    CCDS29336.1
    UniProtKB/Swiss-Prot
    G3X9X6, P70211
    UniProtKB/TrEMBL
    Q3TZP5
    Related
    ENSMUSP00000110593.4, ENSMUST00000114943.11
    Conserved Domains (8) summary
    smart00408
    Location:153219
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:726805
    FN3; Fibronectin type 3 domain
    cd00063
    Location:528617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06583
    Location:11481445
    Neogenin_C; Neogenin C-terminus
    pfam07679
    Location:241327
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:246251
    Ig; Ig strand A' [structural motif]
    cd05722
    Location:39136
    IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
    cd05723
    Location:334417
    IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    71386703..72484299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525588.5XP_006525651.1  netrin receptor DCC isoform X1

    UniProtKB/Swiss-Prot
    P70211
    Related
    ENSMUSP00000073094.6, ENSMUST00000073379.6
    Conserved Domains (7) summary
    cd05722
    Location:42136
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:153219
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:726805
    FN3; Fibronectin type 3 domain
    cd00063
    Location:528617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06583
    Location:11281425
    Neogenin_C; Neogenin C-terminus
    pfam07679
    Location:241327
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:347417
    Ig; Immunoglobulin domain