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Dcc deleted in colorectal carcinoma [ Mus musculus (house mouse) ]

Gene ID: 13176, updated on 21-Sep-2021

Summary

Official Symbol
Dccprovided by MGI
Official Full Name
deleted in colorectal carcinomaprovided by MGI
Primary source
MGI:MGI:94869
See related
Ensembl:ENSMUSG00000060534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Igdcc; Igdcc1; C030036D22Rik
Expression
Biased expression in whole brain E14.5 (RPKM 7.6), CNS E14 (RPKM 7.4) and 5 other tissues See more
Orthologs
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Genomic context

See Dcc in Genome Data Viewer
Location:
18 E2; 18 45.24 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (71386703..72484299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (71253613..72351228, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (71413286..72510723, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated protein transmembrane 4B pseudogene Neighboring gene ribosomal protein S6 kinase, polypeptide 1 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene predicted gene, 31819

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables netrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
netrin receptor DCC
Names
tumor suppressor protein DCC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007831.3NP_031857.2  netrin receptor DCC precursor

    See identical proteins and their annotated locations for NP_031857.2

    Status: VALIDATED

    Source sequence(s)
    AC136637, AK090377, AK157715, BQ550935, CN665025
    Consensus CDS
    CCDS29336.1
    UniProtKB/Swiss-Prot
    P70211
    UniProtKB/TrEMBL
    Q3TZP5
    Related
    ENSMUSP00000110593.4, ENSMUST00000114943.11
    Conserved Domains (8) summary
    cd05722
    Location:42136
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:153219
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:726805
    FN3; Fibronectin type 3 domain
    smart00410
    Location:147224
    IG_like; Immunoglobulin like
    cd00063
    Location:528617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:241327
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11481445
    Neogenin_C; Neogenin C-terminus
    cl11960
    Location:347417
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    71386703..72484299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525588.5XP_006525651.1  netrin receptor DCC isoform X1

    UniProtKB/Swiss-Prot
    P70211
    Related
    ENSMUSP00000073094.6, ENSMUST00000073379.6
    Conserved Domains (7) summary
    cd05722
    Location:42136
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:153219
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:726805
    FN3; Fibronectin type 3 domain
    cd00063
    Location:528617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06583
    Location:11281425
    Neogenin_C; Neogenin C-terminus
    pfam07679
    Location:241327
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:347417
    Ig; Immunoglobulin domain
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