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SLC31A1 solute carrier family 31 member 1 [ Homo sapiens (human) ]

Gene ID: 1317, updated on 13-Mar-2020

Summary

Official Symbol
SLC31A1provided by HGNC
Official Full Name
solute carrier family 31 member 1provided by HGNC
Primary source
HGNC:HGNC:11016
See related
Ensembl:ENSG00000136868 MIM:603085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTR1; COPT1
Summary
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in liver (RPKM 33.0), duodenum (RPKM 22.8) and 25 other tissues See more
Orthologs

Genomic context

See SLC31A1 in Genome Data Viewer
Location:
9q32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113221544..113264492)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115983808..116026772)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7760 Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase 15 Neighboring gene uncharacterized LOC107987119 Neighboring gene cell division cycle 26 Neighboring gene pre-mRNA processing factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75487

Gene Ontology Provided by GOA

Function Evidence Code Pubs
copper ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
copper ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular copper ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
copper ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
copper ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
late endosome IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
high affinity copper uptake protein 1
Names
copper transport 1 homolog
copper transporter 1
solute carrier family 31 (copper transporter), member 1
solute carrier family 31 (copper transporters), member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001859.4NP_001850.1  high affinity copper uptake protein 1

    See identical proteins and their annotated locations for NP_001850.1

    Status: REVIEWED

    Source sequence(s)
    AL449305, AL831843, BC013611
    Consensus CDS
    CCDS6789.1
    UniProtKB/Swiss-Prot
    O15431
    UniProtKB/TrEMBL
    A0A024R824
    Related
    ENSP00000363329.4, ENST00000374212.5
    Conserved Domains (1) summary
    pfam04145
    Location:45175
    Ctr; Ctr copper transporter family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113221544..113264492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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