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Dbh dopamine beta hydroxylase [ Mus musculus (house mouse) ]

Gene ID: 13166, updated on 8-Feb-2024

Summary

Official Symbol
Dbhprovided by MGI
Official Full Name
dopamine beta hydroxylaseprovided by MGI
Primary source
MGI:MGI:94864
See related
Ensembl:ENSMUSG00000000889 AllianceGenome:MGI:94864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Involved in catecholamine metabolic process; locomotory behavior; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including behavioral response to ethanol; homoiothermy; and learning or memory. Located in secretory granule lumen and secretory granule membrane. Is expressed in several structures, including adrenal gland; alimentary system; and nervous system. Used to study dopamine beta-hydroxylase deficiency. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward adrenal adult (RPKM 151.1) See more
Orthologs
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Genomic context

See Dbh in Genome Data Viewer
Location:
2 A3; 2 19.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27055519..27073216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27165507..27183204)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26977601-26977932 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26981648-26981757 Neighboring gene family with sequence similarity 163, member B Neighboring gene dopamine beta hydroxylase, opposite strand Neighboring gene sarcosine dehydrogenase Neighboring gene vav 2 oncogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R5 erythroid cis-regulatory module

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables dopamine beta-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dopamine beta-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within catecholamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within dopamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homoiothermy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in octopamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in octopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dopamine beta-hydroxylase
Names
dopamine beta-monooxygenase
NP_620392.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138942.3NP_620392.2  dopamine beta-hydroxylase

    See identical proteins and their annotated locations for NP_620392.2

    Status: VALIDATED

    Source sequence(s)
    AK132245, BB109310
    Consensus CDS
    CCDS38088.1
    UniProtKB/Swiss-Prot
    Q3V1U4, Q64237
    Related
    ENSMUSP00000000910.7, ENSMUST00000000910.7
    Conserved Domains (3) summary
    pfam01082
    Location:217344
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03351
    Location:61176
    DOMON; DOMON domain
    pfam03712
    Location:365520
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    27055519..27073216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)