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TMEM42 transmembrane protein 42 [ Homo sapiens (human) ]

Gene ID: 131616, updated on 3-May-2025
Official Symbol
TMEM42provided by HGNC
Official Full Name
transmembrane protein 42provided by HGNC
Primary source
HGNC:HGNC:28444
See related
Ensembl:ENSG00000169964 AllianceGenome:HGNC:28444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in testis (RPKM 12.3), thyroid (RPKM 8.6) and 25 other tissues See more
Orthologs
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See TMEM42 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44861912..44865664)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44877631..44881388)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44903404..44907156)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene KIAA1143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene kinesin family member 15 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19772 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14274 Neighboring gene microRNA 564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:44925386-44926063 Neighboring gene peptidylprolyl isomerase A pseudogene 18 Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene transglutaminase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44940040-44940581

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC29956

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transmembrane protein 42

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144638.3NP_653239.1  transmembrane protein 42

    See identical proteins and their annotated locations for NP_653239.1

    Status: VALIDATED

    Source sequence(s)
    AL532443, BC019851, DB499198
    Consensus CDS
    CCDS2722.1
    UniProtKB/Swiss-Prot
    Q69YG0, Q8WUQ6
    Related
    ENSP00000306564.4, ENST00000302392.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44861912..44865664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    387262..391014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44877631..44881388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)