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TPRA1 transmembrane protein adipocyte associated 1 [ Homo sapiens (human) ]

Gene ID: 131601, updated on 13-Mar-2020

Summary

Official Symbol
TPRA1provided by HGNC
Official Full Name
transmembrane protein adipocyte associated 1provided by HGNC
Primary source
HGNC:HGNC:30413
See related
Ensembl:ENSG00000163870 MIM:608336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR175; TPRA40; TMEM227
Expression
Ubiquitous expression in placenta (RPKM 7.3), endometrium (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See TPRA1 in Genome Data Viewer
Location:
3q21.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (127571232..127598231, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127291907..127309602, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2016 Neighboring gene uncharacterized LOC105374094 Neighboring gene long intergenic non-protein coding RNA 1471 Neighboring gene long intergenic non-protein coding RNA 2034 Neighboring gene microRNA 6825 Neighboring gene microRNA 7976 Neighboring gene uncharacterized LOC107986126 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene podocalyxin like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging TAS
Traceable Author Statement
more info
PubMed 
embryonic cleavage IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein adipocyte-associated 1
Names
G protein-coupled receptor 175
integral membrane protein GPR175
seven transmembrane domain orphan receptor
transmembrane domain protein regulated in adipocytes 40 kDa
transmembrane protein 227
transmembrane protein, adipocyte asscociated 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136053.4NP_001129525.1  transmembrane protein adipocyte-associated 1 isoform 1

    See identical proteins and their annotated locations for NP_001129525.1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BC050711, BM670609, HY066741
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000347748.3, ENST00000355552.8
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  2. NM_001142646.4NP_001136118.1  transmembrane protein adipocyte-associated 1 isoform 2

    See identical proteins and their annotated locations for NP_001136118.1

    Status: VALIDATED

    Source sequence(s)
    AC084035, AF289568, BC050711, BM670609, HY066741
    Consensus CDS
    CCDS46899.1
    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000296210.7, ENST00000296210.11
    Conserved Domains (1) summary
    pfam10160
    Location:39203
    Tmemb_40; Predicted membrane protein
  3. NM_001353001.2NP_001339930.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  4. NM_001353002.2NP_001339931.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609, CF132113
    Consensus CDS
    CCDS3042.1
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  5. NM_001353003.2NP_001339932.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  6. NM_001353004.2NP_001339933.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    Related
    ENSP00000498161.1, ENST00000648957.1
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  7. NM_001353005.2NP_001339934.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein
  8. NM_001353006.2NP_001339935.1  transmembrane protein adipocyte-associated 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609
    Conserved Domains (1) summary
    pfam10160
    Location:39166
    Tmemb_40; Predicted membrane protein
  9. NM_001353007.2NP_001339936.1  transmembrane protein adipocyte-associated 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Conserved Domains (1) summary
    pfam10160
    Location:39275
    Tmemb_40; Predicted membrane protein

RNA

  1. NR_073377.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084035, BC017058, BM670609, HY066741
  2. NR_148226.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    127571232..127598231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713496.3XP_006713559.1  transmembrane protein adipocyte-associated 1 isoform X1

    See identical proteins and their annotated locations for XP_006713559.1

    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000418298.1, ENST00000489960.5
    Conserved Domains (1) summary
    pfam10160
    Location:39312
    Tmemb_40; Predicted membrane protein

RNA

  1. XR_924102.2 RNA Sequence

  2. XR_001740016.2 RNA Sequence

    Related
    ENST00000393400.6
  3. XR_001740017.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016372.2: Suppressed sequence

    Description
    NM_016372.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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