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LRRC15 leucine rich repeat containing 15 [ Homo sapiens (human) ]

Gene ID: 131578, updated on 13-Mar-2020

Summary

Official Symbol
LRRC15provided by HGNC
Official Full Name
leucine rich repeat containing 15provided by HGNC
Primary source
HGNC:HGNC:20818
See related
Ensembl:ENSG00000172061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIB
Expression
Broad expression in endometrium (RPKM 1.9), gall bladder (RPKM 1.2) and 15 other tissues See more
Orthologs

Genomic context

See LRRC15 in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194355249..194369743, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194075976..194090472, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene carboxypeptidase N subunit 2 Neighboring gene ATPase 13A3 Neighboring gene glycoprotein V platelet

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 15
Names
hLib
leucine-rich repeat protein induced by beta amyloid
leucine-rich repeat protein induced by beta-amyloid homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135057.3NP_001128529.2  leucine-rich repeat-containing protein 15 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC174158, BC101064, BK001325
    Consensus CDS
    CCDS46984.1
    UniProtKB/Swiss-Prot
    Q8TF66
    Related
    ENSP00000413707.1, ENST00000428839.1
    Conserved Domains (5) summary
    cd00116
    Location:63309
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:109156
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:299340
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:180239
    LRR_8; Leucine rich repeat
    cl15307
    Location:429468
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
  2. NM_130830.5NP_570843.2  leucine-rich repeat-containing protein 15 isoform b precursor

    See identical proteins and their annotated locations for NP_570843.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC174158, AK125112
    Consensus CDS
    CCDS3306.1
    UniProtKB/Swiss-Prot
    Q8TF66
    UniProtKB/TrEMBL
    B3KWI4
    Related
    ENSP00000306276.3, ENST00000347624.3
    Conserved Domains (4) summary
    TIGR00864
    Location:396467
    PCC; polycystin cation channel protein
    COG4886
    Location:220405
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:103150
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:149209
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194355249..194369743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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