Format

Send to:

Choose Destination

COPB1 COPI coat complex subunit beta 1 [ Homo sapiens (human) ]

Gene ID: 1315, updated on 9-Feb-2020

Summary

Official Symbol
COPB1provided by HGNC
Official Full Name
COPI coat complex subunit beta 1provided by HGNC
Primary source
HGNC:HGNC:2231
See related
Ensembl:ENSG00000129083 MIM:600959
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COPB
Summary
This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
Expression
Ubiquitous expression in thyroid (RPKM 49.1), prostate (RPKM 35.6) and 25 other tissues See more
Orthologs

Genomic context

See COPB1 in Genome Data Viewer
Location:
11p15.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (14457503..14499895, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14479049..14521441, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 800 Neighboring gene 60S ribosomal protein L13a-like Neighboring gene RNA, U7 small nuclear 49 pseudogene Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene phosphodiesterase 3B Neighboring gene mortality factor 4 like 1 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef utilizes beta-COP in CD28 downregulation PubMed
nef beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
nef MHC-I is found in the Rab7(+) vesicles and targeted for degradation via the activity of the Nef-interacting protein, beta-COP PubMed
nef Binding of HIV-1 Nef to Beta-COP has been demonstrated by yeast two-hybrid and coimmunoprecipitation experiments and may be involved in the downregulation of CD4 by Nef PubMed
nef Co-localization of HIV-1 Nef, ARF1, and Beta-COP in early endosomes depends on Nef residues at E154 and E155; this co-localization is required for the downregulation and transport of CD4 to acidic late-endosomal compartments PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PSMA1

Homology

Clone Names

  • FLJ10341, FLJ46444, FLJ57957, DKFZp761K102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intra-Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPI vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi-associated vesicle TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
coatomer subunit beta
Names
beta coat protein
beta-cop
coatomer protein complex subunit beta 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144061.1NP_001137533.1  coatomer subunit beta

    See identical proteins and their annotated locations for NP_001137533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA443270, AL136593, DA725605, DB455108
    Consensus CDS
    CCDS7815.1
    UniProtKB/Swiss-Prot
    P53618
    Related
    ENSP00000397873.2, ENST00000439561.6
    Conserved Domains (4) summary
    pfam01602
    Location:18550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:816944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform
    sd00044
    Location:137161
    HEAT; HEAT repeat [structural motif]
  2. NM_001144062.1NP_001137534.1  coatomer subunit beta

    See identical proteins and their annotated locations for NP_001137534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA443270, AF111807, DA725605
    Consensus CDS
    CCDS7815.1
    UniProtKB/Swiss-Prot
    P53618
    Conserved Domains (4) summary
    pfam01602
    Location:18550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:816944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform
    sd00044
    Location:137161
    HEAT; HEAT repeat [structural motif]
  3. NM_016451.4NP_057535.1  coatomer subunit beta

    See identical proteins and their annotated locations for NP_057535.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA443270, BC037280, DA725605
    Consensus CDS
    CCDS7815.1
    UniProtKB/Swiss-Prot
    P53618
    Related
    ENSP00000249923.3, ENST00000249923.7
    Conserved Domains (4) summary
    pfam01602
    Location:18550
    Adaptin_N; Adaptin N terminal region
    pfam07718
    Location:667807
    Coatamer_beta_C; Coatomer beta C-terminal region
    pfam14806
    Location:816944
    Coatomer_b_Cpla; Coatomer beta subunit appendage platform
    sd00044
    Location:137161
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    14457503..14499895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center