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CD200R1 CD200 receptor 1 [ Homo sapiens (human) ]

Gene ID: 131450, updated on 16-Feb-2020

Summary

Official Symbol
CD200R1provided by HGNC
Official Full Name
CD200 receptor 1provided by HGNC
Primary source
HGNC:HGNC:24235
See related
Ensembl:ENSG00000163606 MIM:607546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OX2R; MOX2R; CD200R; HCRTR2
Summary
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 4.6), placenta (RPKM 2.9) and 22 other tissues See more
Orthologs

Genomic context

See CD200R1 in Genome Data Viewer
Location:
3q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (112921205..112975103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112641532..112693950, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12929 Neighboring gene CD200R1L antisense RNA 1 Neighboring gene CD200 receptor 1 like Neighboring gene uncharacterized LOC107986114 Neighboring gene GTP binding protein 8 (putative) Neighboring gene nucleolus and neural progenitor protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycosylated region protein binding TAS
Traceable Author Statement
more info
PubMed 
immunoglobulin receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
negative regulation of T cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of interleukin-6 secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of macrophage migration ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell surface glycoprotein CD200 receptor 1
Names
CD200 cell surface glycoprotein receptor
MOX2 receptor
cell surface glycoprotein OX2 receptor 1
cell surface glycoprotein receptor CD200

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138806.4NP_620161.1  cell surface glycoprotein CD200 receptor 1 isoform a precursor

    See identical proteins and their annotated locations for NP_620161.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript variant and encodes the longest isoform (a).
    Source sequence(s)
    AC074044, AF495380, AK126349, AY358910
    Consensus CDS
    CCDS2969.1
    UniProtKB/Swiss-Prot
    Q8TD46
    Related
    ENSP00000311035.3, ENST00000308611.8
    Conserved Domains (1) summary
    cl11960
    Location:188257
    Ig; Immunoglobulin domain
  2. NM_138939.3NP_620385.1  cell surface glycoprotein CD200 receptor 1 isoform b precursor

    See identical proteins and their annotated locations for NP_620385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC074044, AF497549, AK126349
    Consensus CDS
    CCDS46889.1
    UniProtKB/Swiss-Prot
    Q8TD46
    Related
    ENSP00000405733.2, ENST00000440122.6
  3. NM_138940.3NP_620386.1  cell surface glycoprotein CD200 receptor 1 isoform c precursor

    See identical proteins and their annotated locations for NP_620386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1. This results in a frameshift and early stop codon, as well as loss of an immunoglobulin and transmembrane domain in the protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC074044, AF497550, AK126349
    Consensus CDS
    CCDS54623.1
    UniProtKB/Swiss-Prot
    Q8TD46
    Related
    ENSP00000418801.1, ENST00000490004.1
  4. NM_170780.3NP_740750.1  cell surface glycoprotein CD200 receptor 1 isoform d precursor

    See identical proteins and their annotated locations for NP_740750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) utilizes an alternate splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
    Source sequence(s)
    AC074044, AF497548, AK126349
    Consensus CDS
    CCDS2970.1
    UniProtKB/Swiss-Prot
    Q8TD46
    Related
    ENSP00000418928.1, ENST00000471858.5
    Conserved Domains (1) summary
    cl11960
    Location:165234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    112921205..112975103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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