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TRIM71 tripartite motif containing 71 [ Homo sapiens (human) ]

Gene ID: 131405, updated on 28-Nov-2021

Summary

Official Symbol
TRIM71provided by HGNC
Official Full Name
tripartite motif containing 71provided by HGNC
Primary source
HGNC:HGNC:32669
See related
Ensembl:ENSG00000206557 MIM:618570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIN41; HYDCC1; LIN-41
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 4.2), kidney (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

See TRIM71 in Genome Data Viewer
Location:
3p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (32817997..32897824)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32859489..32939316)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23a pseudogene 43 Neighboring gene Sharpr-MPRA regulatory region 2511 Neighboring gene Sharpr-MPRA regulatory region 1778 Neighboring gene C-C motif chemokine receptor 4 Neighboring gene uncharacterized LOC107986072 Neighboring gene galactosidase beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
GeneReviews: Not available
Hydrocephalus, congenital communicating, 1
MedGen: C5231454 OMIM: 618667 GeneReviews: Not available
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Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in miRNA-mediated gene silencing by inhibition of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
involved_in neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
involved_in posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM71
Names
RING-type E3 ubiquitin transferase TRIM71
abnormal cell LINeage LIN-41
homolog of C. elegans Lin-41
protein lin-41 homolog
tripartite motif containing 71, E3 ubiquitin protein ligase
tripartite motif-containing protein 71
NP_001034200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039111.3NP_001034200.1  E3 ubiquitin-protein ligase TRIM71

    See identical proteins and their annotated locations for NP_001034200.1

    Status: REVIEWED

    Source sequence(s)
    AC139452, AW196612, DQ232881
    Consensus CDS
    CCDS43060.1
    UniProtKB/Swiss-Prot
    Q2Q1W2
    Related
    ENSP00000373272.3, ENST00000383763.6
    Conserved Domains (7) summary
    smart00502
    Location:314444
    BBC; B-Box C-terminal domain
    cd14954
    Location:584868
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:704740
    7WD40; WD40 repeat [structural motif]
    cd16589
    Location:897
    RING-HC_TRIM71_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
    cd19796
    Location:277322
    Bbox2_TRIM71_C-VII; B-box-type 2 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
    cd19812
    Location:198240
    Bbox1_TRIM71_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
    pfam00630
    Location:482577
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    32817997..32897824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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