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TRIM71 tripartite motif containing 71 [ Homo sapiens (human) ]

Gene ID: 131405, updated on 11-Sep-2019

Summary

Official Symbol
TRIM71provided by HGNC
Official Full Name
tripartite motif containing 71provided by HGNC
Primary source
HGNC:HGNC:32669
See related
Ensembl:ENSG00000206557 MIM:618570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIN41; LIN-41
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 4.2), kidney (RPKM 0.7) and 1 other tissue See more
Orthologs

Genomic context

See TRIM71 in Genome Data Viewer
Location:
3p22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (32817997..32897824)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32859510..32933771)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2511 Neighboring gene uncharacterized LOC105377021 Neighboring gene uncharacterized LOC105377022 Neighboring gene C-C motif chemokine receptor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
miRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
3'-UTR-mediated mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
miRNA mediated inhibition of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
miRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neural tube development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
posttranscriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
stem cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
P-body IDA
Inferred from Direct Assay
more info
PubMed 
P-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM71
Names
RING-type E3 ubiquitin transferase TRIM71
abnormal cell LINeage LIN-41
homolog of C. elegans Lin-41
protein lin-41 homolog
tripartite motif containing 71, E3 ubiquitin protein ligase
tripartite motif-containing protein 71
NP_001034200.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039111.3NP_001034200.1  E3 ubiquitin-protein ligase TRIM71

    See identical proteins and their annotated locations for NP_001034200.1

    Status: REVIEWED

    Source sequence(s)
    AC139452, AW196612, DQ232881
    Consensus CDS
    CCDS43060.1
    UniProtKB/Swiss-Prot
    Q2Q1W2
    Related
    ENSP00000373272.3, ENST00000383763.6
    Conserved Domains (6) summary
    cd14954
    Location:584868
    NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins
    sd00039
    Location:704740
    7WD40; WD40 repeat [structural motif]
    pfam00630
    Location:482577
    Filamin; Filamin/ABP280 repeat
    pfam00643
    Location:278312
    zf-B_box; B-box zinc finger
    cd16589
    Location:897
    RING-HC_TRIM71_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 71 (TRIM71) and similar proteins
    cl25407
    Location:314444
    ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    32817997..32897824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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