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LYZL4 lysozyme like 4 [ Homo sapiens (human) ]

Gene ID: 131375, updated on 1-Jun-2020

Summary

Official Symbol
LYZL4provided by HGNC
Official Full Name
lysozyme like 4provided by HGNC
Primary source
HGNC:HGNC:28387
See related
Ensembl:ENSG00000157093 MIM:612750
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYC4; LYZA
Summary
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Expression
Restricted expression toward testis (RPKM 6.7) See more
Orthologs

Genomic context

See LYZL4 in Genome Data Viewer
Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (42360766..42411794, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42438575..42452125, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene spalt like transcription factor 4 pseudogene 6 Neighboring gene eukaryotic translation initiation factor 4B pseudogene 4 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene vasoactive intestinal peptide receptor 1 Neighboring gene VIPR1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC26768, 1810009N24Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lysozyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus HDA PubMed 
sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
lysozyme-like protein 4
Names
lysozyme A
lysozyme-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304386.2NP_001291315.1  lysozyme-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001291315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092048, BC016747, BX282166, HY037577
    Consensus CDS
    CCDS2697.1
    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
    Related
    ENSP00000387897.1, ENST00000441172.1
    Conserved Domains (1) summary
    cd00119
    Location:20142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  2. NM_144634.4NP_653235.1  lysozyme-like protein 4 precursor

    See identical proteins and their annotated locations for NP_653235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC092048, BC016747, HY037577
    Consensus CDS
    CCDS2697.1
    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
    Related
    ENSP00000287748.3, ENST00000287748.8
    Conserved Domains (1) summary
    cd00119
    Location:20142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    42360766..42411794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533355.3XP_011531657.1  lysozyme-like protein 4 isoform X2

    Conserved Domains (1) summary
    cd00119
    Location:20123
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  2. XM_024453345.1XP_024309113.1  lysozyme-like protein 4 isoform X1

    Conserved Domains (1) summary
    cd00119
    Location:20142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
  3. XM_017005706.1XP_016861195.1  lysozyme-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q96KX0
    UniProtKB/TrEMBL
    A0A080YUZ5
    Conserved Domains (1) summary
    cd00119
    Location:20142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
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