Dab1 disabled 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dab1provided by MGI
Official Full Name: disabled 1provided by MGI
Primary source: MGI:MGI:108554
See related: Ensembl:ENSMUSG00000028519 AllianceGenome:MGI:108554
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: scm; scr; yot; scrambler; C630028C02Rik
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity. Involved in lateral motor column neuron migration. Acts upstream of or within several processes, including adult walking behavior; negative regulation of receptor signaling pathway via JAK-STAT; and nervous system development. Located in perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to human DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 14.1), whole brain E14.5 (RPKM 10.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 47.79 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (103476425..104602041)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (103619500..104744844)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice.
Title: Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1-/- (yotari) Mice.
Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
Title: Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
Title: Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
A Homozygous Dab1(-/-) Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract.
Title: A Homozygous Dab1-/- Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract.
Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Title: Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.
Title: Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.
Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
Title: Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
Title: Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
Reelin and its downstream molecules, including Dab1, play crucial roles in the neural regeneration and subsequent recovery of motor function in our hemiplegic mouse model
Title: Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts.
Findings illustrate a DCC-Dab1 interaction that ensures proper neuronal migration during neocortical development.
Title: DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (7) 1 citation
Targeted (11) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI956902 (e-PCR)
- UniSTS:179037

D4Mit46.3 (e-PCR), detects polymorphism
- UniSTS:130164

Dab1 (e-PCR), detects polymorphism
- UniSTS:506834

Dab1 (e-PCR), detects polymorphism
- UniSTS:142824

Dab1 (e-PCR), detects polymorphism
- UniSTS:142825

Homology

Homologs of the Dab1 gene: The Dab1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 460 organisms have orthologs with human gene Dab1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH2 domain binding	TAS Traceable Author Statement more info	PubMed
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cerebellum structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in lateral motor column neuron migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in lateral motor column neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within radial glia guided migration of Purkinje cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within radial glia guided migration of Purkinje cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within radial glia-guided pyramidal neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within small GTPase mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ventral spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disabled homolog 1

Names: yotari

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369046.1 → NP_001355975.1 disabled homolog 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 2 and 5, encodes isoform 2.

Source sequence(s)

AL626762, AL627134, AL645483, AL645666, AL669938, AL772211

Consensus CDS

CCDS18413.1

UniProtKB/TrEMBL

A0A6P5PQF7, B2RRQ8

Conserved Domains (2) summary

PRK07764
Location:255 → 436

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001369047.1 → NP_001355976.1 disabled homolog 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variants 2 and 4, encodes isoform 2.

Source sequence(s)

AL626762, AL627134, AL645483, AL645666, AL669938, AL772211

Consensus CDS

CCDS18413.1

UniProtKB/TrEMBL

A0A6P5PQF7, B2RRQ8

Conserved Domains (2) summary

PRK07764
Location:255 → 436

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001369048.1 → NP_001355977.1 disabled homolog 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL626762, AL627134, AL645483, AL645666, AL669938, AL772211

Consensus CDS

CCDS89790.1

UniProtKB/TrEMBL

A0A8C6GTH6

Related

ENSMUSP00000102440.2, ENSMUST00000106827.8

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001369049.1 → NP_001355978.1 disabled homolog 1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (7) encodes the longest isoform (4).

Source sequence(s)

AL626762, AL627134, AL645483, AL645666, AL669938, AL772211

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_010014.3 → NP_034144.1 disabled homolog 1 isoform 1

See identical proteins and their annotated locations for NP_034144.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 2.

Source sequence(s)

BE947086, BY264959, Y08381

UniProtKB/Swiss-Prot

P97318

Related

ENSMUSP00000102439.2, ENSMUST00000106826.8

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_177259.4 → NP_796233.2 disabled homolog 1 isoform 2

See identical proteins and their annotated locations for NP_796233.2

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variants 4 and 5, encodes isoform 2.

Source sequence(s)

AK045616, BC138538, BE945099, BY264959, Y08379

Consensus CDS

CCDS18413.1

UniProtKB/Swiss-Prot

P97318

UniProtKB/TrEMBL

A0A6P5PQF7, B2RRQ8

Related

ENSMUSP00000102443.3, ENSMUST00000106830.9

Conserved Domains (2) summary

PRK07764
Location:255 → 436

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

RNA

NR_104385.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL627134, AL645483, AL669938

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

103476425..104602041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163642.1 → XP_036019535.1 disabled homolog 1 isoform X5

UniProtKB/TrEMBL

A0A6P7R5Y7

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163645.1 → XP_036019538.1 disabled homolog 1 isoform X15

UniProtKB/TrEMBL

A0A8C6GTH6

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_006502725.5 → XP_006502788.1 disabled homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006502788.1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163638.1 → XP_036019531.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163640.1 → XP_036019533.1 disabled homolog 1 isoform X4

UniProtKB/TrEMBL

A0A6P5PQF7, B2RRQ8

Conserved Domains (2) summary

PRK07764
Location:255 → 436

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163635.1 → XP_036019528.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_011240426.3 → XP_011238728.1 disabled homolog 1 isoform X1

See identical proteins and their annotated locations for XP_011238728.1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163636.1 → XP_036019529.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253166.2 → XP_030109026.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163637.1 → XP_036019530.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163641.1 → XP_036019534.1 disabled homolog 1 isoform X5

UniProtKB/TrEMBL

A0A6P7R5Y7

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163633.1 → XP_036019526.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163632.1 → XP_036019525.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253165.2 → XP_030109025.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_017319948.2 → XP_017175437.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253172.2 → XP_030109032.1 disabled homolog 1 isoform X5

UniProtKB/TrEMBL

A0A6P7R5Y7

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_006502727.5 → XP_006502790.1 disabled homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006502790.1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253170.2 → XP_030109030.1 disabled homolog 1 isoform X4

UniProtKB/TrEMBL

A0A6P5PQF7, B2RRQ8

Conserved Domains (2) summary

PRK07764
Location:255 → 436

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253175.2 → XP_030109035.1 disabled homolog 1 isoform X8

Conserved Domains (2) summary

PHA03247
Location:254 → 434

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253182.2 → XP_030109042.1 disabled homolog 1 isoform X15

UniProtKB/TrEMBL

A0A8C6GTH6

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163643.1 → XP_036019536.1 disabled homolog 1 isoform X12

Conserved Domains (2) summary

PRK07764
Location:220 → 401

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163644.1 → XP_036019537.1 disabled homolog 1 isoform X14

Conserved Domains (2) summary

PRK07764
Location:220 → 401

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253180.2 → XP_030109040.1 disabled homolog 1 isoform X15

UniProtKB/TrEMBL

A0A8C6GTH6

Conserved Domains (1) summary

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253169.2 → XP_030109029.1 disabled homolog 1 isoform X3

UniProtKB/TrEMBL

A0A6P7QVA6

Conserved Domains (2) summary

PHA03247
Location:287 → 467

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253177.2 → XP_030109037.1 disabled homolog 1 isoform X10

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_006502726.2 → XP_006502789.1 disabled homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006502789.1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253174.1 → XP_030109034.1 disabled homolog 1 isoform X7

Conserved Domains (2) summary

PRK07764
Location:251 → 432

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253167.2 → XP_030109027.1 disabled homolog 1 isoform X2

Conserved Domains (2) summary

PRK07764
Location:286 → 467

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253173.2 → XP_030109033.1 disabled homolog 1 isoform X6

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253171.1 → XP_030109031.1 disabled homolog 1 isoform X5

UniProtKB/TrEMBL

A0A6P7R5Y7

Conserved Domains (2) summary

PRK07764
Location:253 → 434

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_017319950.3 → XP_017175439.1 disabled homolog 1 isoform X8

Conserved Domains (2) summary

PHA03247
Location:254 → 434

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253176.2 → XP_030109036.1 disabled homolog 1 isoform X9

Conserved Domains (2) summary

PHA03247
Location:252 → 432

PHA03247; large tegument protein UL36; Provisional

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253178.1 → XP_030109038.1 disabled homolog 1 isoform X12

Conserved Domains (2) summary

PRK07764
Location:220 → 401

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_030253179.2 → XP_030109039.1 disabled homolog 1 isoform X13

Conserved Domains (2) summary

PRK07764
Location:218 → 399

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_036163639.1 → XP_036019532.1 disabled homolog 1 isoform X1

Conserved Domains (2) summary

PRK07764
Location:288 → 469

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd01215
Location:25 → 174

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
XM_006502735.3 → XP_006502798.1 disabled homolog 1 isoform X11

Conserved Domains (2) summary

PRK07764
Location:224 → 405

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cl17171
Location:1 → 110

PH-like; Pleckstrin homology-like domain