Format

Send to:

Choose Destination

Dab1 disabled 1 [ Mus musculus (house mouse) ]

Gene ID: 13131, updated on 11-Sep-2019

Summary

Official Symbol
Dab1provided by MGI
Official Full Name
disabled 1provided by MGI
Primary source
MGI:MGI:108554
See related
Ensembl:ENSMUSG00000028519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
scm; scr; yot; AI956902; scrambler; C630028C02Rik
Expression
Biased expression in CNS E18 (RPKM 14.1), whole brain E14.5 (RPKM 10.9) and 11 other tissues See more
Orthologs

Genomic context

See Dab1 in Genome Data Viewer
Location:
4 C6; 4 47.79 cM
Exon count:
29
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103619500..104744844)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (104040165..104417447)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA66 Neighboring gene predicted gene, 36604 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 36661 Neighboring gene complement component 8, beta polypeptide Neighboring gene FYN binding protein 2 Neighboring gene complement component 8, alpha polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
cerebellum structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex radially oriented cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
cerebral cortex radially oriented cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex radially oriented cell migration ISO
Inferred from Sequence Orthology
more info
 
dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
lateral motor column neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lateral motor column neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
radial glia guided migration of Purkinje cell IGI
Inferred from Genetic Interaction
more info
PubMed 
radial glia guided migration of Purkinje cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
small GTPase mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventral spinal cord development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ventral spinal cord development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
brush border ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear region of cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disabled homolog 1
Names
yotari

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369046.1NP_001355975.1  disabled homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2 and 5, encodes isoform 2.
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Conserved Domains (2) summary
    PRK07764
    Location:255436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  2. NM_001369047.1NP_001355976.1  disabled homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2 and 4, encodes isoform 2.
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Conserved Domains (2) summary
    PRK07764
    Location:255436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  3. NM_001369048.1NP_001355977.1  disabled homolog 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Related
    ENSMUSP00000102440.1, ENSMUST00000106827.7
    Conserved Domains (1) summary
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  4. NM_001369049.1NP_001355978.1  disabled homolog 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (4).
    Source sequence(s)
    AL626762, AL627134, AL645483, AL645666, AL669938, AL772211
    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  5. NM_010014.3NP_034144.1  disabled homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_034144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks several exons and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    BE947086, BY264959, Y08381
    UniProtKB/Swiss-Prot
    P97318
    Related
    ENSMUSP00000102439.1, ENSMUST00000106826.7
    Conserved Domains (1) summary
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  6. NM_177259.4NP_796233.2  disabled homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_796233.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 4 and 5, encodes isoform 2.
    Source sequence(s)
    AK045616, BC138538, BE945099, BY264959, Y08379
    Consensus CDS
    CCDS18413.1
    UniProtKB/Swiss-Prot
    P97318
    UniProtKB/TrEMBL
    B2RRQ8
    Related
    ENSMUSP00000102443.2, ENSMUST00000106830.8
    Conserved Domains (2) summary
    PRK07764
    Location:255436
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain

RNA

  1. NR_104385.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL627134, AL645483, AL669938

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p6 C57BL/6J

    Range
    103619500..104744844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253166.1XP_030109026.1  disabled homolog 1 isoform X1

  2. XM_006502725.4XP_006502788.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502788.1

    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  3. XM_017319949.2XP_017175438.1  disabled homolog 1 isoform X8

  4. XM_011240426.2XP_011238728.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011238728.1

    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  5. XM_030253165.1XP_030109025.1  disabled homolog 1 isoform X1

  6. XM_017319948.1XP_017175437.1  disabled homolog 1 isoform X1

    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  7. XM_006502727.4XP_006502790.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502790.1

    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  8. XM_030253170.1XP_030109030.1  disabled homolog 1 isoform X4

  9. XM_030253172.1XP_030109032.1  disabled homolog 1 isoform X5

  10. XM_030253175.1XP_030109035.1  disabled homolog 1 isoform X8

  11. XM_030253182.1XP_030109042.1  disabled homolog 1 isoform X14

  12. XM_030253180.1XP_030109040.1  disabled homolog 1 isoform X14

  13. XM_030253169.1XP_030109029.1  disabled homolog 1 isoform X3

  14. XM_030253177.1XP_030109037.1  disabled homolog 1 isoform X10

  15. XM_006502726.2XP_006502789.1  disabled homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006502789.1

    Conserved Domains (2) summary
    PRK07764
    Location:288469
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01215
    Location:25174
    PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
  16. XM_030253167.1XP_030109027.1  disabled homolog 1 isoform X2

  17. XM_030253176.1XP_030109036.1  disabled homolog 1 isoform X9

  18. XM_030253173.1XP_030109033.1  disabled homolog 1 isoform X6

  19. XM_030253174.1XP_030109034.1  disabled homolog 1 isoform X7

  20. XM_017319950.2XP_017175439.1  disabled homolog 1 isoform X8

  21. XM_030253171.1XP_030109031.1  disabled homolog 1 isoform X5

  22. XM_030253179.1XP_030109039.1  disabled homolog 1 isoform X13

  23. XM_030253178.1XP_030109038.1  disabled homolog 1 isoform X12

  24. XM_006502735.2XP_006502798.1  disabled homolog 1 isoform X11

    Conserved Domains (1) summary
    cl17171
    Location:1110
    PH-like; Pleckstrin homology-like domain
Support Center