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Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 [ Mus musculus (house mouse) ]

Gene ID: 13117, updated on 8-Feb-2024

Summary

Official Symbol
Cyp4a10provided by MGI
Official Full Name
cytochrome P450, family 4, subfamily a, polypeptide 10provided by MGI
Primary source
MGI:MGI:88611
See related
Ensembl:ENSMUSG00000066072 AllianceGenome:MGI:88611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RP1; Cyp4a; D4Rp1; Msp-3
Summary
Predicted to enable 16-hydroxypalmitate dehydrogenase activity and monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to act upstream of or within lipid metabolic process. Located in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension. Orthologous to several human genes including CYP4A11 (cytochrome P450 family 4 subfamily A member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 205.5), kidney adult (RPKM 150.4) and 1 other tissue See more
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Genomic context

See Cyp4a10 in Genome Data Viewer
Location:
4 D1; 4 53.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115375484..115390846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115518287..115533649)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12833 Neighboring gene predicted gene, 52676 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 14 Neighboring gene STARR-seq mESC enhancer starr_11120 Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_11121 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 31

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alkane 1-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables arachidonic acid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in icosanoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in icosanoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lauric acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lauric acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 4A10
Names
CYPIVA10
cytochrome P450, 4a10
cytochrome P450-LA-omega 1
cytochrome P452
lauric acid omega-hydroxylase
long-chain fatty acid omega-monooxygenase
NP_034141.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010011.3NP_034141.3  cytochrome P450 4A10

    See identical proteins and their annotated locations for NP_034141.3

    Status: VALIDATED

    Source sequence(s)
    AI042822, AK002528
    Consensus CDS
    CCDS18492.1
    UniProtKB/Swiss-Prot
    A2A976, O88833, Q9DCS5
    UniProtKB/TrEMBL
    A2A977
    Related
    ENSMUSP00000061126.4, ENSMUST00000058785.10
    Conserved Domains (1) summary
    pfam00067
    Location:52503
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115375484..115390846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)