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Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 [ Mus musculus (house mouse) ]

Gene ID: 13112, updated on 8-Dec-2022

Summary

Official Symbol
Cyp3a11provided by MGI
Official Full Name
cytochrome P450, family 3, subfamily a, polypeptide 11provided by MGI
Primary source
MGI:MGI:88609
See related
Ensembl:ENSMUSG00000056035 AllianceGenome:MGI:88609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcn; Cyp3a; IIIAm1
Summary
Enables monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4) and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 331.5) See more
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Genomic context

See Cyp3a11 in Genome Data Viewer
Location:
5 G2; 5 85.17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145791417..145816664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145854607..145879854, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 44 pseudogene Neighboring gene predicted gene, 38744 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 25 Neighboring gene predicted gene 8454

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in alkaloid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid hydroxylation ISO
Inferred from Sequence Orthology
more info
 
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oxidative demethylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 3A11
Names
CYPIIIA11
cytochrome P-450IIIAM1
cytochrome P-450UT
cytochrome P450, steroid inducible 3a11
steroid inducible
NP_031844.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007818.3NP_031844.1  cytochrome P450 3A11

    See identical proteins and their annotated locations for NP_031844.1

    Status: PROVISIONAL

    Source sequence(s)
    AC111090, AC166648
    Consensus CDS
    CCDS19865.1
    UniProtKB/Swiss-Prot
    Q64459
    UniProtKB/TrEMBL
    Q3UEN8
    Related
    ENSMUSP00000037665.8, ENSMUST00000035918.8
    Conserved Domains (1) summary
    pfam00067
    Location:39494
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145791417..145816664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)