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Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 13110, updated on 6-Jun-2024

Summary

Official Symbol
Cyp2j6provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily j, polypeptide 6provided by MGI
Primary source
MGI:MGI:1270148
See related
Ensembl:ENSMUSG00000052914 AllianceGenome:MGI:1270148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arachidonic acid epoxygenase activity. Predicted to be involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and unsaturated fatty acid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension (multiple); myocardial infarction; and renal fibrosis. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 4.6), large intestine adult (RPKM 2.5) and 22 other tissues See more
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Genomic context

See Cyp2j6 in Genome Data Viewer
Location:
4 C5; 4 44.62 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96404375..96449835, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96516138..96564305, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily j, member 14, pseudogene Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 9 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid 11,12-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid 14,15-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid epoxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables linoleic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2J6
Names
CYPIIJ6
arachidonic acid epoxygenase
cytochrome P450, 2j6
NP_001407757.1
NP_034138.3
XP_006502785.1
XP_030109023.1
XP_036019523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420828.1NP_001407757.1  cytochrome P450 2J6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683816
    UniProtKB/TrEMBL
    Q8CC91
  2. NM_010008.5NP_034138.3  cytochrome P450 2J6 isoform 1

    See identical proteins and their annotated locations for NP_034138.3

    Status: VALIDATED

    Source sequence(s)
    AL683816
    Consensus CDS
    CCDS18369.1
    UniProtKB/Swiss-Prot
    O54750, Q8BR78
    UniProtKB/TrEMBL
    Q8CC91
    Related
    ENSMUSP00000030303.5, ENSMUST00000030303.6
    Conserved Domains (1) summary
    pfam00067
    Location:44496
    p450; Cytochrome P450

RNA

  1. NR_185201.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816
  2. NR_185202.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816
  3. NR_185203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683816

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    96404375..96449835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502722.5XP_006502785.1  cytochrome P450 2J6 isoform X4

    Conserved Domains (1) summary
    cl41757
    Location:1259
    cytochrome_P450; cytochrome P450 (CYP) superfamily
  2. XM_036163630.1XP_036019523.1  cytochrome P450 2J6 isoform X4

    Conserved Domains (1) summary
    cl41757
    Location:1259
    cytochrome_P450; cytochrome P450 (CYP) superfamily
  3. XM_030253163.2XP_030109023.1  cytochrome P450 2J6 isoform X5

    Conserved Domains (1) summary
    cl12078
    Location:44229
    p450; Cytochrome P450