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Cyp2d10 cytochrome P450, family 2, subfamily d, polypeptide 10 [ Mus musculus (house mouse) ]

Gene ID: 13101, updated on 27-Nov-2024

Summary

Official Symbol
Cyp2d10provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily d, polypeptide 10provided by MGI
Primary source
MGI:MGI:88602
See related
Ensembl:ENSMUSG00000094806 AllianceGenome:MGI:88602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp2d; P450-2D
Summary
Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in alimentary system; liver; and urinary system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 533.6), liver E18 (RPKM 67.5) and 1 other tissue See more
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Genomic context

See Cyp2d10 in Genome Data Viewer
Location:
15 E1; 15 38.58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82287046..82291449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82402845..82407253, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 22 Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 11 Neighboring gene microRNA 7684 Neighboring gene predicted gene, 19267 Neighboring gene predicted gene, 46501

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome P450 2D10
Names
CYPIID10
cytochrome P450, 2d10
cytochrome P450-16-alpha
cytochrome P450CB
testosterone 16-alpha hydroxylase
NP_034135.2
XP_006520454.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010005.3NP_034135.2  cytochrome P450 2D10

    See identical proteins and their annotated locations for NP_034135.2

    Status: VALIDATED

    Source sequence(s)
    AA239803, AI323751, BF660186, CA457792, CB951489
    Consensus CDS
    CCDS27690.1
    UniProtKB/Swiss-Prot
    P24456, Q64490
    Related
    ENSMUSP00000072555.4, ENSMUST00000072776.5
    Conserved Domains (1) summary
    pfam00067
    Location:37496
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82287046..82291449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520391.5XP_006520454.1  cytochrome P450 2D10 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:37437
    p450; Cytochrome P450