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ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [ Homo sapiens (human) ]

Gene ID: 131, updated on 3-Jan-2019

Summary

Official Symbol
ADH7provided by HGNC
Official Full Name
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by HGNC
Primary source
HGNC:HGNC:256
See related
Ensembl:ENSG00000196344 MIM:600086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADH4
Summary
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression
Restricted expression toward esophagus (RPKM 95.5) See more
Orthologs

Genomic context

See ADH7 in Genome Data Viewer
Location:
4q23
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (99412261..99435510, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (100333418..100356667, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ADH1C promoter region Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide Neighboring gene uncharacterized LOC102723576 Neighboring gene D-E enhancer region downstream of ADH7 Neighboring gene ADH7 promoter Neighboring gene chromosome 4 open reading frame 17 Neighboring gene tRNA methyltransferase 10A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of hypertension and blood pressure in African Americans.
NHGRI GWA Catalog
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
NHGRI GWA Catalog
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
NHGRI GWA Catalog
Genetic variants associated with disordered eating.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alcohol dehydrogenase (NAD) activity TAS
Traceable Author Statement
more info
PubMed 
alcohol dehydrogenase activity, zinc-dependent EXP
Inferred from Experiment
more info
PubMed 
alcohol dehydrogenase activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alcohol dehydrogenase activity, zinc-dependent IDA
Inferred from Direct Assay
more info
PubMed 
aldehyde oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
ethanol binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor antagonist activity IDA
Inferred from Direct Assay
more info
PubMed 
retinol binding IDA
Inferred from Direct Assay
more info
PubMed 
retinol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ethanol catabolic process IEA
Inferred from Electronic Annotation
more info
 
ethanol oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ethanol oxidation IDA
Inferred from Direct Assay
more info
PubMed 
ethanol oxidation TAS
Traceable Author Statement
more info
 
extracellular negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
fatty acid omega-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
alcohol dehydrogenase class 4 mu/sigma chain
Names
alcohol dehydrogenase VII
alcohol dehydrogenase class IV mu/sigma chain
alcohol dehydrogenase-7
class IV sigma-1 alcohol dehydrogenase
class IV sigmasigma alcohol dehydrogenase
gastric alcohol dehydrogenase
retinol dehydrogenase
NP_000664.2
NP_001159976.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000673.4NP_000664.2  alcohol dehydrogenase class 4 mu/sigma chain isoform 2

    See identical proteins and their annotated locations for NP_000664.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC131512, CA311897, DB204496
    Consensus CDS
    CCDS34034.1
    UniProtKB/Swiss-Prot
    P40394
    Related
    ENSP00000209665.4, ENST00000209665.8
    Conserved Domains (1) summary
    cd08299
    Location:15386
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
  2. NM_001166504.1NP_001159976.1  alcohol dehydrogenase class 4 mu/sigma chain isoform 1

    See identical proteins and their annotated locations for NP_001159976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    AK301696, CA311897, CD014081, DB350054
    Consensus CDS
    CCDS54781.1
    UniProtKB/Swiss-Prot
    P40394
    Related
    ENSP00000420269.1, ENST00000476959.5
    Conserved Domains (2) summary
    cd08299
    Location:27394
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
    COG1062
    Location:28394
    FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    99412261..99435510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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