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M1AP meiosis 1 associated protein [ Homo sapiens (human) ]

Gene ID: 130951, updated on 20-Mar-2020

Summary

Official Symbol
M1APprovided by HGNC
Official Full Name
meiosis 1 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:25183
See related
Ensembl:ENSG00000159374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D6Mm5e; C2orf65; SPATA37
Summary
This gene encodes a protein that is likely to function in progression of meiosis. A similar protein in mouse plays a role in gametogenesis in both sexes. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 3.3), bone marrow (RPKM 2.4) and 8 other tissues See more
Orthologs

Genomic context

See M1AP in Genome Data Viewer
Location:
2p13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74557640..74648338, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74785010..74875994, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase like 3 Neighboring gene docking protein 1 Neighboring gene TOR1B pseudogene 1 Neighboring gene TVP23B pseudogene 2 Neighboring gene ssemaphorin 4F Neighboring gene uncharacterized LOC105374808

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA processing NAS
Non-traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chromatin assembly NAS
Non-traceable Author Statement
more info
PubMed 
female gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
male meiosis chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male meiosis chromosome separation ISS
Inferred from Sequence or Structural Similarity
more info
 
meiosis I IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
meiosis 1 arrest protein
Names
meiosis 1 arresting protein
spermatogenesis associated 37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281295.2NP_001268224.1  meiosis 1 arrest protein isoform 2

    See identical proteins and their annotated locations for NP_001268224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks several exons at its 3' end, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC014602, DR158220
    UniProtKB/Swiss-Prot
    Q8TC57
  2. NM_001281296.1NP_001268225.1  meiosis 1 arrest protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR and lacks an in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AK300188, BC025997, DR158220
    Consensus CDS
    CCDS62941.1
    UniProtKB/Swiss-Prot
    Q8TC57
    Related
    ENSP00000445662.1, ENST00000536235.5
  3. NM_001321739.2NP_001308668.1  meiosis 1 arrest protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    BC025997, DR158220
    Consensus CDS
    CCDS33229.1
    UniProtKB/Swiss-Prot
    Q8TC57
  4. NM_138804.4NP_620159.2  meiosis 1 arrest protein isoform 1

    See identical proteins and their annotated locations for NP_620159.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007387, BC025997
    Consensus CDS
    CCDS33229.1
    UniProtKB/Swiss-Prot
    Q8TC57
    Related
    ENSP00000290536.5, ENST00000290536.9

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74557640..74648338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452711.1XP_024308479.1  meiosis 1 arrest protein isoform X1

  2. XM_011532549.2XP_011530851.1  meiosis 1 arrest protein isoform X4

  3. XM_011532552.2XP_011530854.1  meiosis 1 arrest protein isoform X6

  4. XM_011532548.2XP_011530850.1  meiosis 1 arrest protein isoform X3

  5. XM_006711946.3XP_006712009.1  meiosis 1 arrest protein isoform X2

  6. XM_011532551.2XP_011530853.1  meiosis 1 arrest protein isoform X5

    See identical proteins and their annotated locations for XP_011530853.1

    UniProtKB/Swiss-Prot
    Q8TC57
  7. XM_011532550.2XP_011530852.1  meiosis 1 arrest protein isoform X5

    See identical proteins and their annotated locations for XP_011530852.1

    UniProtKB/Swiss-Prot
    Q8TC57
  8. XM_005264152.3XP_005264209.1  meiosis 1 arrest protein isoform X9

    See identical proteins and their annotated locations for XP_005264209.1

    UniProtKB/TrEMBL
    B3KX03
    Related
    ENST00000464686.5
  9. XM_011532554.2XP_011530856.1  meiosis 1 arrest protein isoform X8

  10. XM_011532553.2XP_011530855.1  meiosis 1 arrest protein isoform X7

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