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Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13082, updated on 25-May-2024

Summary

Official Symbol
Cyp26a1provided by MGI
Official Full Name
cytochrome P450, family 26, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:1096359
See related
Ensembl:ENSMUSG00000024987 AllianceGenome:MGI:1096359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAH; Cyp26; P450RA; P450RAI
Summary
Enables retinoic acid 4-hydroxylase activity. Involved in retinoic acid catabolic process. Acts upstream of or within several processes, including anterior/posterior pattern specification; cellular response to retinoic acid; and neural crest cell development. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; extraembryonic component; and sensory organ. Orthologous to human CYP26A1 (cytochrome P450 family 26 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 38.3) and ovary adult (RPKM 6.7) See more
Orthologs
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Genomic context

See Cyp26a1 in Genome Data Viewer
Location:
19 C2; 19 32.36 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37686186..37689984)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37697738..37701536)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 6 Neighboring gene predicted gene, 41842 Neighboring gene STARR-seq mESC enhancer starr_46060 Neighboring gene STARR-seq mESC enhancer starr_46061 Neighboring gene STARR-seq mESC enhancer starr_46062 Neighboring gene predicted gene, 32342 Neighboring gene cytochrome P450, family 26, subfamily c, polypeptide 1 Neighboring gene high mobility group box 1-like pseudogene Neighboring gene protease (prosome, macropain) 26S subunit, ATPase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC13860

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in retinoic acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in retinoic acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinoic acid receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 26A1
Names
cytochrome P450, 26, retinoic acid A1
cytochrome P450RAI
retinoic acid 4-hydroxylase
retinoic acid hydrolase
retinoic acid-metabolizing cytochrome
NP_031837.2
XP_017173542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007811.2NP_031837.2  cytochrome P450 26A1

    See identical proteins and their annotated locations for NP_031837.2

    Status: VALIDATED

    Source sequence(s)
    AA239785, CB574526, CJ217321, CK626921
    Consensus CDS
    CCDS29780.1
    UniProtKB/Swiss-Prot
    O55127, Q9R1F4
    UniProtKB/TrEMBL
    A0A0R4J061
    Related
    ENSMUSP00000025946.6, ENSMUST00000025946.7
    Conserved Domains (1) summary
    cl12078
    Location:43491
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    37686186..37689984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318053.2XP_017173542.1  cytochrome P450 26A1 isoform X1

    UniProtKB/Swiss-Prot
    O55127, Q9R1F4
    Conserved Domains (1) summary
    cl12078
    Location:4422
    p450; Cytochrome P450