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SLC66A3 solute carrier family 66 member 3 [ Homo sapiens (human) ]

Gene ID: 130814, updated on 11-Jun-2021

Summary

Official Symbol
SLC66A3provided by HGNC
Official Full Name
solute carrier family 66 member 3provided by HGNC
Primary source
HGNC:HGNC:28503
See related
Ensembl:ENSG00000162976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PQLC3; C2orf22
Expression
Ubiquitous expression in spleen (RPKM 9.0), gall bladder (RPKM 7.5) and 25 other tissues See more
Orthologs
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Genomic context

See SLC66A3 in Genome Data Viewer
Location:
2p25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (11155372..11182028)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11295593..11318982)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285150 Neighboring gene ribosomal protein L6 pseudogene 4 Neighboring gene chromosome 2 open reading frame 50 Neighboring gene Rho associated coiled-coil containing protein kinase 2 Neighboring gene RNA, U6 small nuclear 1081, pseudogene Neighboring gene AIDA pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33602

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 66 member 3
Names
PQ loop repeat containing 3
PQ-loop repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282710.2NP_001269639.1  solute carrier family 66 member 3 isoform b

    See identical proteins and their annotated locations for NP_001269639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK001091, AK301439, BQ574369, DB460796
    Consensus CDS
    CCDS62856.1
    UniProtKB/Swiss-Prot
    Q8N755
    Related
    ENSP00000406148.2, ENST00000441908.6
  2. NM_001282711.2NP_001269640.1  solute carrier family 66 member 3 isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK001091, AK301439, BQ574369, CX751769, DC392668
    Consensus CDS
    CCDS62857.1
    UniProtKB/Swiss-Prot
    Q8N755
    UniProtKB/TrEMBL
    B5MC27
    Related
    ENSP00000384129.1, ENST00000402361.5
  3. NM_001282712.2NP_001269641.1  solute carrier family 66 member 3 isoform d precursor

    See identical proteins and their annotated locations for NP_001269641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons in the 3' coding region and uses an alternate splice site in the central region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC018463, AK001091, BQ277359, BQ574369, DC392668
    UniProtKB/Swiss-Prot
    Q8N755
  4. NM_152391.5NP_689604.1  solute carrier family 66 member 3 isoform a precursor

    See identical proteins and their annotated locations for NP_689604.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK001091, BQ574369
    Consensus CDS
    CCDS1679.1
    UniProtKB/Swiss-Prot
    Q8N755
    Related
    ENSP00000295083.3, ENST00000295083.8

RNA

  1. NR_104231.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK001091, BI601351, BQ574369

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    11155372..11182028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510315.2XP_011508617.1  solute carrier family 66 member 3 isoform X1

RNA

  1. XR_001738633.1 RNA Sequence

  2. XR_001738632.2 RNA Sequence

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