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Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13081, updated on 12-May-2024

Summary

Official Symbol
Cyp24a1provided by MGI
Official Full Name
cytochrome P450, family 24, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88593
See related
Ensembl:ENSMUSG00000038567 AllianceGenome:MGI:88593
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CP24; Cyp24; 24-OHase
Summary
The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward kidney adult (RPKM 11.8) See more
Orthologs
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Genomic context

See Cyp24a1 in Genome Data Viewer
Location:
2 H3; 2 91.91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170324877..170339065, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170482957..170497145, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06529 Neighboring gene predicted gene, 34608 Neighboring gene predicted gene, 40000 Neighboring gene prefoldin 4 Neighboring gene predicted gene, 16796 Neighboring gene STARR-positive B cell enhancer ABC_E9211 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:170334342-170334495 Neighboring gene STARR-positive B cell enhancer ABC_E822 Neighboring gene STARR-seq mESC enhancer starr_06531 Neighboring gene STARR-seq mESC enhancer starr_06532 Neighboring gene predicted gene, 40001

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129158, MGC129159

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables 25-hydroxycholecalciferol-23-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables 25-hydroxycholecalciferol-24-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 25-hydroxycholecalciferol-24-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 25-hydroxycholecalciferol-24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables vitamin D 25-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vitamin D 25-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin D IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
involved_in vitamin D catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vitamin D catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vitamin D metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vitamin D metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Names
25-hydroxyvitamin D-24-hydroxylase
cytochrome P450 24A1
cytochrome P450, 24
cytochrome P450, 24a1
cytochrome P450-CC24
vitamin D(3) 24-hydroxylase
NP_034126.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009996.4NP_034126.1  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_034126.1

    Status: REVIEWED

    Source sequence(s)
    AK159852
    Consensus CDS
    CCDS17122.1
    UniProtKB/Swiss-Prot
    Q64441
    UniProtKB/TrEMBL
    Q3TWW0, Q3TXU0
    Related
    ENSMUSP00000047954.6, ENSMUST00000038824.6
    Conserved Domains (1) summary
    pfam00067
    Location:59513
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    170324877..170339065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)