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ZFAND2B zinc finger AN1-type containing 2B [ Homo sapiens (human) ]

Gene ID: 130617, updated on 15-Jun-2019

Summary

Official Symbol
ZFAND2Bprovided by HGNC
Official Full Name
zinc finger AN1-type containing 2Bprovided by HGNC
Primary source
HGNC:HGNC:25206
See related
Ensembl:ENSG00000158552 MIM:613474
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIRAPL
Summary
This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in thyroid (RPKM 23.0), duodenum (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See ZFAND2B in Genome Data Viewer
Location:
2q35
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (219206784..219209651)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220071506..220074373)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 23 member 3 Neighboring gene cyclin Pas1/PHO80 domain containing 1 Neighboring gene reticulophagy regulator family member 2 Neighboring gene ATP binding cassette subfamily B member 6 (Langereis blood group) Neighboring gene autophagy related 9A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
K48-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AN1-type zinc finger protein 2B
Names
AIRAP-like protein
arsenite-inducible RNA-associated protein-like protein
zinc finger, AN1-type domain 2B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270998.1NP_001257927.1  AN1-type zinc finger protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001257927.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC068946, BC018415, BM852092, BU195818
    Consensus CDS
    CCDS2435.1
    UniProtKB/Swiss-Prot
    Q8WV99
    UniProtKB/TrEMBL
    A0A024R435
    Related
    ENSP00000411334.3, ENST00000444522.6
    Conserved Domains (3) summary
    pfam01428
    Location:100136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197212
    UIM; Ubiquitin interaction motif
    pfam06012
    Location:139244
    DUF908; Domain of Unknown Function (DUF908)
  2. NM_001270999.1NP_001257928.1  AN1-type zinc finger protein 2B isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC068946, BC018415, BE742808, BM852092
    Consensus CDS
    CCDS74656.1
    UniProtKB/Swiss-Prot
    Q8WV99
    UniProtKB/TrEMBL
    A0A087X0D9
    Related
    ENSP00000483320.1, ENST00000621130.4
    Conserved Domains (2) summary
    pfam01428
    Location:5692
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:153168
    UIM; Ubiquitin interaction motif
  3. NM_138802.3NP_620157.1  AN1-type zinc finger protein 2B isoform 1

    See identical proteins and their annotated locations for NP_620157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC068946, BC018415, BM852092
    Consensus CDS
    CCDS2435.1
    UniProtKB/Swiss-Prot
    Q8WV99
    UniProtKB/TrEMBL
    A0A024R435
    Related
    ENSP00000289528.5, ENST00000289528.10
    Conserved Domains (3) summary
    pfam01428
    Location:100136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197212
    UIM; Ubiquitin interaction motif
    pfam06012
    Location:139244
    DUF908; Domain of Unknown Function (DUF908)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    219206782..219209651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003368.1XP_016858857.1  AN1-type zinc finger protein 2B isoform X2

    UniProtKB/Swiss-Prot
    Q8WV99
    UniProtKB/TrEMBL
    A0A024R435
    Related
    ENSP00000386898.1, ENST00000409336.5
    Conserved Domains (3) summary
    pfam01428
    Location:100136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197212
    UIM; Ubiquitin interaction motif
    pfam06012
    Location:139244
    DUF908; Domain of Unknown Function (DUF908)
  2. XM_006712286.3XP_006712349.1  AN1-type zinc finger protein 2B isoform X1

    See identical proteins and their annotated locations for XP_006712349.1

    Conserved Domains (2) summary
    pfam01428
    Location:100136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197212
    UIM; Ubiquitin interaction motif
  3. XM_006712285.1XP_006712348.1  AN1-type zinc finger protein 2B isoform X1

    See identical proteins and their annotated locations for XP_006712348.1

    Conserved Domains (2) summary
    pfam01428
    Location:100136
    zf-AN1; AN1-like Zinc finger
    pfam02809
    Location:197212
    UIM; Ubiquitin interaction motif
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