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TMEM198 transmembrane protein 198 [ Homo sapiens (human) ]

Gene ID: 130612, updated on 25-Jan-2022

Summary

Official Symbol
TMEM198provided by HGNC
Official Full Name
transmembrane protein 198provided by HGNC
Primary source
HGNC:HGNC:33704
See related
Ensembl:ENSG00000188760 AllianceGenome:HGNC:33704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM198A
Summary
Involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in brain (RPKM 5.5), duodenum (RPKM 3.9) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM198 in Genome Data Viewer
Location:
2q35
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (219543663..219550595)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220408385..220415317)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASIC4 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4906 Neighboring gene acid sensing ion channel subunit family member 4 Neighboring gene chondroitin polymerizing factor Neighboring gene microRNA 3132 Neighboring gene obscurin like cytoskeletal adaptor 1 Neighboring gene Sharpr-MPRA regulatory region 8831 Neighboring gene Sharpr-MPRA regulatory region 8639

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ41180, MGC99813

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005209.3NP_001005209.1  transmembrane protein 198

    See identical proteins and their annotated locations for NP_001005209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009955
    Consensus CDS
    CCDS33385.1
    UniProtKB/Swiss-Prot
    Q66K66
    UniProtKB/TrEMBL
    A0A024R483
    Related
    ENSP00000362990.3, ENST00000373883.4
    Conserved Domains (1) summary
    pfam13886
    Location:41204
    DUF4203; Domain of unknown function (DUF4203)
  2. NM_001303098.2NP_001290027.1  transmembrane protein 198

    See identical proteins and their annotated locations for NP_001290027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC009955
    Consensus CDS
    CCDS33385.1
    UniProtKB/Swiss-Prot
    Q66K66
    UniProtKB/TrEMBL
    A0A024R483
    Related
    ENSP00000343507.2, ENST00000344458.6
    Conserved Domains (1) summary
    pfam13886
    Location:41204
    DUF4203; Domain of unknown function (DUF4203)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    219543663..219550595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003367.2XP_016858856.1  transmembrane protein 198 isoform X1

    UniProtKB/Swiss-Prot
    Q66K66
    UniProtKB/TrEMBL
    A0A024R483
    Conserved Domains (1) summary
    pfam13886
    Location:41204
    DUF4203; Domain of unknown function (DUF4203)
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