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LYPD6 LY6/PLAUR domain containing 6 [ Homo sapiens (human) ]

Gene ID: 130574, updated on 23-Nov-2021

Summary

Official Symbol
LYPD6provided by HGNC
Official Full Name
LY6/PLAUR domain containing 6provided by HGNC
Primary source
HGNC:HGNC:28751
See related
Ensembl:ENSG00000187123 MIM:613359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]
Expression
Biased expression in gall bladder (RPKM 7.3), placenta (RPKM 6.8) and 12 other tissues See more
Orthologs
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Genomic context

See LYPD6 in Genome Data Viewer
Location:
2q23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (149329985..149474138)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (150186499..150330652)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373679 Neighboring gene family with sequence similarity 8 member A3, pseudogene Neighboring gene microRNA 9899 Neighboring gene ribosomal protein L17 pseudogene 13 Neighboring gene MMADHC divergent transcript Neighboring gene metabolism of cobalamin associated D Neighboring gene RNA, U6 small nuclear 601, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC52057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables acetylcholine receptor inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195685.2NP_001182614.1  ly6/PLAUR domain-containing protein 6 precursor

    See identical proteins and their annotated locations for NP_001182614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007394
    Consensus CDS
    CCDS2188.1
    UniProtKB/Swiss-Prot
    Q86Y78
    Related
    ENSP00000386413.1, ENST00000409381.5
    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
  2. NM_194317.5NP_919298.1  ly6/PLAUR domain-containing protein 6 precursor

    See identical proteins and their annotated locations for NP_919298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC007394
    Consensus CDS
    CCDS2188.1
    UniProtKB/Swiss-Prot
    Q86Y78
    Related
    ENSP00000334463.4, ENST00000334166.9
    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    149329985..149474138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452700.1XP_024308468.1  ly6/PLAUR domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
  2. XM_024452698.1XP_024308466.1  ly6/PLAUR domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
  3. XM_024452699.1XP_024308467.1  ly6/PLAUR domain-containing protein 6 isoform X1

    Related
    ENSP00000498455.1, ENST00000651933.1
    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
  4. XM_024452701.1XP_024308469.1  ly6/PLAUR domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    pfam16975
    Location:41145
    UPAR_LY6_2; Ly6/PLAUR domain-containing protein 6, Lypd6
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