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Cyba cytochrome b-245, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13057, updated on 26-Sep-2022

Summary

Official Symbol
Cybaprovided by MGI
Official Full Name
cytochrome b-245, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:1316658
See related
Ensembl:ENSMUSG00000006519 AllianceGenome:MGI:1316658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b558; nmf333; p22phox; p22-phox
Summary
Predicted to enable SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Predicted to contribute to superoxide-generating NAD(P)H oxidase activity. Involved in innate immune response. Acts upstream of or within positive regulation of mucus secretion; reactive oxygen species metabolic process; and regulation of release of sequestered calcium ion into cytosol. Located in endosome. Part of NADPH oxidase complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; inner ear; limb; and liver. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Orthologous to human CYBA (cytochrome b-245 alpha chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 399.2), spleen adult (RPKM 288.4) and 19 other tissues See more
Orthologs
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Genomic context

See Cyba in Genome Data Viewer
Location:
8; 8 E1
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123151510..123159679, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122424771..122432940, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 18 Neighboring gene interleukin 17C Neighboring gene predicted gene, 53466 Neighboring gene mevalonate (diphospho) decarboxylase Neighboring gene predicted gene, 51557

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to superoxide-generating NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cytochrome complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glomerular filtration by angiotensin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in respiratory burst ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide anion generation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NADPH oxidase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytochrome b-245 light chain
Names
cytochrome b(558) alpha chain
cytochrome b558 subunit alpha
cytochrome beta-558
neutrophil cytochrome b 22 kDa polypeptide
p22 phagocyte B-cytochrome
p22 phox
superoxide-generating NADPH oxidase light chain subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301284.1NP_001288213.1  cytochrome b-245 light chain isoform 2

    See identical proteins and their annotated locations for NP_001288213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant . The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK018713, AL591003, BC060635
    Consensus CDS
    CCDS85623.1
    UniProtKB/Swiss-Prot
    Q61462
    UniProtKB/TrEMBL
    A0A8C6MWI5
    Related
    ENSMUSP00000148320.2, ENSMUST00000212600.2
    Conserved Domains (1) summary
    pfam05038
    Location:9162
    Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit
  2. NM_007806.3NP_031832.2  cytochrome b-245 light chain isoform 1

    See identical proteins and their annotated locations for NP_031832.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK152414, BY005999, CF738398
    Consensus CDS
    CCDS22737.1
    UniProtKB/Swiss-Prot
    Q61462, Q9D2W2
    UniProtKB/TrEMBL
    A0A6P5Q2Z7, A0A8C6H9C2, B3VQI8
    Related
    ENSMUSP00000017604.9, ENSMUST00000017604.10
    Conserved Domains (1) summary
    pfam05038
    Location:9190
    Cytochrom_B558a; Cytochrome Cytochrome b558 alpha-subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123151510..123159679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)