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Cyb561 cytochrome b-561 [ Mus musculus (house mouse) ]

Gene ID: 13056, updated on 5-Jan-2023

Summary

Official Symbol
Cyb561provided by MGI
Official Full Name
cytochrome b-561provided by MGI
Primary source
MGI:MGI:103253
See related
Ensembl:ENSMUSG00000019590 AllianceGenome:MGI:103253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis and cellular iron ion homeostasis. Located in chromaffin granule membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; node; and nose. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 144.4), adrenal adult (RPKM 27.6) and 12 other tissues See more
Orthologs
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Genomic context

See Cyb561 in Genome Data Viewer
Location:
11 E1; 11 68.81 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105824528..105844157, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105933702..105945019, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane monodehydroascorbate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ascorbate homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromaffin granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane ascorbate-dependent reductase CYB561; cytochrome b561
Names
CGCytb
chromaffin granule Cyt b561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356374.1NP_001343303.1  transmembrane ascorbate-dependent reductase CYB561

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK158978, AL596246, AW985556
    Consensus CDS
    CCDS25542.1
    UniProtKB/Swiss-Prot
    Q9D6C9
    Conserved Domains (1) summary
    cl23723
    Location:43184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  2. NM_007805.5NP_031831.2  transmembrane ascorbate-dependent reductase CYB561

    See identical proteins and their annotated locations for NP_031831.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK014395, AK028780, AL596246, AW985556
    Consensus CDS
    CCDS25542.1
    UniProtKB/Swiss-Prot
    Q60720, Q9D6C9
    Related
    ENSMUSP00000019734.5, ENSMUST00000019734.11
    Conserved Domains (1) summary
    cl23723
    Location:43184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105824528..105844157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156276.1XP_036012169.1  cytochrome b561 isoform X1

    Conserved Domains (1) summary
    cd08763
    Location:81222
    Cyt_b561_CYB561; Vertebrate cytochrome b(561), CYB561 gene product
  2. XM_036156277.1XP_036012170.1  cytochrome b561 isoform X2

    Conserved Domains (1) summary
    cl23723
    Location:53194
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  3. XM_006532131.4XP_006532194.1  cytochrome b561 isoform X3

    See identical proteins and their annotated locations for XP_006532194.1

    UniProtKB/Swiss-Prot
    Q60720, Q9D6C9
    Conserved Domains (1) summary
    cl23723
    Location:43184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  4. XM_006532132.5XP_006532195.1  cytochrome b561 isoform X3

    See identical proteins and their annotated locations for XP_006532195.1

    UniProtKB/Swiss-Prot
    Q60720, Q9D6C9
    Conserved Domains (1) summary
    cl23723
    Location:43184
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  5. XM_036156278.1XP_036012171.1  cytochrome b561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Conserved Domains (1) summary
    cl23723
    Location:43174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  6. XM_036156279.1XP_036012172.1  cytochrome b561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Conserved Domains (1) summary
    cl23723
    Location:43174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
  7. XM_006532134.5XP_006532197.1  cytochrome b561 isoform X4

    UniProtKB/TrEMBL
    V9GX11
    Related
    ENSMUSP00000138931.2, ENSMUST00000184086.8
    Conserved Domains (1) summary
    cl23723
    Location:43174
    Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...