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Ctsl cathepsin L [ Mus musculus (house mouse) ]

Gene ID: 13039, updated on 8-Feb-2024

Summary

Official Symbol
Ctslprovided by MGI
Official Full Name
cathepsin Lprovided by MGI
Primary source
MGI:MGI:88564
See related
Ensembl:ENSMUSG00000021477 AllianceGenome:MGI:88564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
fs; MEP; nkt; CatL; Ctsl1; 1190035F06Rik
Summary
This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]
Expression
Broad expression in placenta adult (RPKM 194.5), liver E18 (RPKM 75.5) and 20 other tissues See more
Orthologs
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Genomic context

See Ctsl in Genome Data Viewer
Location:
13 B3; 13 33.26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (64509704..64518586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (64361890..64370772, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34827 Neighboring gene peroxiredoxin like 2C Neighboring gene STARR-positive B cell enhancer ABC_E8894 Neighboring gene STARR-positive B cell enhancer ABC_E1879 Neighboring gene predicted gene, 31128 Neighboring gene STARR-positive B cell enhancer ABC_E3084 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64509468-64509621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64511983-64512222 Neighboring gene RIKEN cDNA 1700015C15 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:64533677-64533786 Neighboring gene cyclin dependent kinase 20 Neighboring gene predicted gene, 31218 Neighboring gene BTB (POZ) domain containing 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (7)  1 citation
  • Radiation induced (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables kininogen binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables serpin family protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antigen processing and presentation of peptide antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within catagen IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within decidualization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in elastin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis involved in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thyroid hormone generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in multivesicular body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
procathepsin L
Names
Cat L
cathepsin L1
major excreted protein
p39 cysteine proteinase
NP_034114.1
XP_006517143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009984.4NP_034114.1  procathepsin L preproprotein

    See identical proteins and their annotated locations for NP_034114.1

    Status: REVIEWED

    Source sequence(s)
    AK049466, AV023994, CJ076620, CT030159
    Consensus CDS
    CCDS26600.1
    UniProtKB/Swiss-Prot
    P06797, Q91UZ0
    UniProtKB/TrEMBL
    Q3TNC8, Q3TT75, Q3TVJ1, Q3U5U9, Q3UHZ4, Q543M3, Q9D0C0
    Related
    ENSMUSP00000021933.8, ENSMUST00000021933.8
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114331
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    64509704..64518586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517080.2XP_006517143.1  procathepsin L isoform X1

    See identical proteins and their annotated locations for XP_006517143.1

    UniProtKB/Swiss-Prot
    P06797, Q91UZ0
    UniProtKB/TrEMBL
    Q3TNC8, Q3TT75, Q3TVJ1, Q3U5U9, Q3UHZ4, Q543M3, Q9D0C0
    Conserved Domains (2) summary
    smart00848
    Location:2987
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114331
    Peptidase_C1; Papain family cysteine protease