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RFTN2 raftlin family member 2 [ Homo sapiens (human) ]

Gene ID: 130132, updated on 23-Nov-2021

Summary

Official Symbol
RFTN2provided by HGNC
Official Full Name
raftlin family member 2provided by HGNC
Primary source
HGNC:HGNC:26402
See related
Ensembl:ENSG00000162944 MIM:618215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2orf11; Raftlin-2
Expression
Broad expression in brain (RPKM 9.8), fat (RPKM 3.7) and 18 other tissues See more
Orthologs
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Genomic context

See RFTN2 in Genome Data Viewer
Location:
2q33.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (197568224..197675794, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198432948..198540311, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene MOB family member 4, phocein Neighboring gene RNY5 pseudogene 2 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial Neighboring gene boule homolog, RNA binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30574, MGC117313

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in dsRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
raftlin-2
Names
raft-linking protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144629.3NP_653230.2  raftlin-2

    See identical proteins and their annotated locations for NP_653230.2

    Status: VALIDATED

    Source sequence(s)
    AC020550, AK055136, BC039690, BC113361
    Consensus CDS
    CCDS2323.1
    UniProtKB/Swiss-Prot
    Q52LD8
    Related
    ENSP00000295049.3, ENST00000295049.9
    Conserved Domains (1) summary
    pfam15250
    Location:1439
    Raftlin; Raftlin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    197568224..197675794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003332.2XP_016858821.1  raftlin-2 isoform X5

  2. XM_011510598.3XP_011508900.1  raftlin-2 isoform X4

    Conserved Domains (1) summary
    pfam15250
    Location:1432
    Raftlin; Raftlin
  3. XM_011510597.3XP_011508899.1  raftlin-2 isoform X3

    Conserved Domains (1) summary
    pfam15250
    Location:1438
    Raftlin; Raftlin
  4. XM_011510596.3XP_011508898.1  raftlin-2 isoform X2

    Conserved Domains (1) summary
    pfam15250
    Location:1448
    Raftlin; Raftlin
  5. XM_011510595.3XP_011508897.1  raftlin-2 isoform X1

    Conserved Domains (1) summary
    pfam15250
    Location:1449
    Raftlin; Raftlin
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