Cst9 cystatin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cst9provided by MGI
Official Full Name: cystatin 9provided by MGI
Primary source: MGI:MGI:1340053
See related: Ensembl:ENSMUSG00000027445 AllianceGenome:MGI:1340053
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M12; cresp; testatin
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in antimicrobial humoral response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; gut; male reproductive gland or organ; and urogenital ridge. Orthologous to several human genes including CST9L (cystatin 9 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 86.6) See more
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Genomic context

Location:: 2; 2 G3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148677067..148680657)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148835147..148838737)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

decrease of endogenous testatin in female gonad is not critical, and the increase of testatin in male gonad is dispensable for sex-differentiation
Title: Testatin transgenic and knockout mice exhibit normal sex-differentiation.
Results show no abnormalities in testatin knockout mice with regard to fetal and adult testis morphology, cellular ultrastructure, body and testis weight, number of offspring, spermatogenesis, or hormonal parameters.
Title: Normal sexual development and fertility in testatin knockout mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Cst9 (e-PCR), detects polymorphism
- UniSTS:464660

Cst9 (e-PCR), detects polymorphism
- UniSTS:525893

Cst9 (e-PCR), detects polymorphism
- UniSTS:275890

Cst9 (e-PCR), detects polymorphism
- UniSTS:516589

Cst9 (e-PCR), detects polymorphism
- UniSTS:516590

Homology

Homologs of the Cst9 gene: The Cst9 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in antimicrobial humoral response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cystatin-9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009979.1 → NP_034109.1 cystatin-9 precursor

See identical proteins and their annotated locations for NP_034109.1

Status: PROVISIONAL

Source sequence(s)

Y18243

Consensus CDS

CCDS16850.1

UniProtKB/Swiss-Prot

Q545L7, Q9Z0H6

Related

ENSMUSP00000028935.4, ENSMUST00000028935.4

Conserved Domains (1) summary

cl09238
Location:43 → 136

CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.