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REG3G regenerating family member 3 gamma [ Homo sapiens (human) ]

Gene ID: 130120, updated on 12-Aug-2018

Summary

Official Symbol
REG3Gprovided by HGNC
Official Full Name
regenerating family member 3 gammaprovided by HGNC
Primary source
HGNC:HGNC:29595
See related
Ensembl:ENSG00000143954 MIM:609933; Vega:OTTHUMG00000130018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III
Summary
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
Expression
Restricted expression toward testis (RPKM 33.7) See more
Orthologs

Genomic context

See REG3G in Genome Data Viewer
Location:
2p12
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (79025664..79028504)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79252812..79255630)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 812, pseudogene Neighboring gene uncharacterized LOC105374822 Neighboring gene regenerating family member 1 beta Neighboring gene regenerating family member 1 alpha

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
NHGRI GWA Catalog

Pathways from BioSystems

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

General gene information

Markers

Homology

Clone Names

  • MGC118998, MGC118999, MGC119001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
PubMed 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
cell wall disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell wall disruption in other organism IDA
Inferred from Direct Assay
more info
PubMed 
cytolysis in other organism IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
regenerating islet-derived protein 3-gamma
Names
REG-3-gamma
pancreatitis-associated protein 1B
pancreatitis-associated protein IB
reg III-gamma
regenerating gene III
regenerating islet-derived 3 gamma
regenerating islet-derived protein III-gamma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008387.2NP_001008388.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001008388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AB161038, AK292595, BX280299
    Consensus CDS
    CCDS1962.1
    UniProtKB/Swiss-Prot
    Q6UW15
    Related
    ENSP00000272324.5, OTTHUMP00000202565, ENST00000272324.9, OTTHUMT00000328247
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  2. NM_001270040.1NP_001256969.1  regenerating islet-derived protein 3-gamma isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001256969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AK292595, BC103852, BX280299
    Consensus CDS
    CCDS58714.1
    UniProtKB/Swiss-Prot
    Q6UW15
    Related
    ENSP00000387105.1, OTTHUMP00000202566, ENST00000409471.1, OTTHUMT00000328248
    Conserved Domains (1) summary
    cl02432
    Location:40127
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  3. NM_198448.3NP_940850.1  regenerating islet-derived protein 3-gamma isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_940850.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK292595, BX280299
    Consensus CDS
    CCDS1962.1
    UniProtKB/Swiss-Prot
    Q6UW15
    Related
    ENSP00000377475.2, OTTHUMP00000160487, ENST00000393897.6, OTTHUMT00000252291
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    79025664..79028504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452694.1XP_024308462.1  regenerating islet-derived protein 3-gamma isoform X2

    Conserved Domains (1) summary
    cl02432
    Location:40127
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  2. XM_005264135.2XP_005264192.1  regenerating islet-derived protein 3-gamma isoform X1

    See identical proteins and their annotated locations for XP_005264192.1

    UniProtKB/Swiss-Prot
    Q6UW15
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  3. XM_024452693.1XP_024308461.1  regenerating islet-derived protein 3-gamma isoform X2

    Conserved Domains (1) summary
    cl02432
    Location:40127
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
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