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CIB4 calcium and integrin binding family member 4 [ Homo sapiens (human) ]

Gene ID: 130106, updated on 5-Jan-2022

Summary

Official Symbol
CIB4provided by HGNC
Official Full Name
calcium and integrin binding family member 4provided by HGNC
Primary source
HGNC:HGNC:33703
See related
Ensembl:ENSG00000157884 MIM:610646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIP4
Summary
Enables calcium ion binding activity and magnesium ion binding activity. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CIB4 in Genome Data Viewer
Location:
2p23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (26581205..26641798, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26804073..26864234, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 888 Neighboring gene otoferlin Neighboring gene family with sequence similarity 166 member C Neighboring gene Sharpr-MPRA regulatory region 9124 Neighboring gene ribosomal protein L37 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
calcium and integrin-binding family member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029881.3NP_001025052.1  calcium and integrin-binding family member 4

    See identical proteins and their annotated locations for NP_001025052.1

    Status: VALIDATED

    Source sequence(s)
    AC015977, AW138422, BC127684
    Consensus CDS
    CCDS33160.1
    UniProtKB/Swiss-Prot
    A0PJX0
    Related
    ENSP00000288861.4, ENST00000288861.5
    Conserved Domains (1) summary
    pfam13499
    Location:101168
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    26581205..26641798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532514.2XP_011530816.1  calcium and integrin-binding family member 4 isoform X1

    See identical proteins and their annotated locations for XP_011530816.1

    Conserved Domains (2) summary
    cd00051
    Location:117185
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:118184
    EF-hand_7; EF-hand domain pair
  2. XM_017003329.1XP_016858818.1  calcium and integrin-binding family member 4 isoform X2

  3. XM_017003330.2XP_016858819.1  calcium and integrin-binding family member 4 isoform X4

  4. XM_017003331.1XP_016858820.1  calcium and integrin-binding family member 4 isoform X5

  5. XM_024452692.1XP_024308460.1  calcium and integrin-binding family member 4 isoform X3

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