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Csnk2b casein kinase 2, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13001, updated on 12-May-2024

Summary

Official Symbol
Csnk2bprovided by MGI
Official Full Name
casein kinase 2, beta polypeptideprovided by MGI
Primary source
MGI:MGI:88548
See related
Ensembl:ENSMUSG00000024387 AllianceGenome:MGI:88548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK II beta
Summary
This gene encodes the beta subunit of the casein kinase 2 enzyme, which is a heterotetramer comprised of alpha and/or alpha-prime catalytic subunits and two regulatory beta subunits. Casein kinase 2 is involved in the regulation of several cellular processes including gene expression, protein synthesis and cell proliferation. Knockout of this gene in mice leads to embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Broad expression in testis adult (RPKM 540.1), duodenum adult (RPKM 75.4) and 23 other tissues See more
Orthologs
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Genomic context

See Csnk2b in Genome Data Viewer
Location:
17 B1; 17 18.59 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35335171..35341029, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35116195..35122053, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7527 Neighboring gene abhydrolase domain containing 16A Neighboring gene lymphocyte antigen 6 family member G5C Neighboring gene lymphocyte antigen 6 family member G5B Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene predicted gene 20522 Neighboring gene DNA segment, Chr 17, human D6S53E

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Ly6g5b

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein kinase CK2 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
casein kinase II subunit beta
Names
phosvitin
NP_001290374.1
NP_001290375.1
NP_001290405.1
NP_034105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303445.1NP_001290374.1  casein kinase II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001290374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28684.1
    UniProtKB/Swiss-Prot
    P67871, Q3TTJ7
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000134218.2, ENSMUST00000173114.8
    Conserved Domains (1) summary
    smart01085
    Location:8191
    CK_II_beta; Casein kinase II regulatory subunit
  2. NM_001303446.1NP_001290375.1  casein kinase II subunit beta isoform 1

    See identical proteins and their annotated locations for NP_001290375.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000134523.3, ENSMUST00000172765.9
    Conserved Domains (1) summary
    smart01085
    Location:29212
    CK_II_beta; Casein kinase II regulatory subunit
  3. NM_001303476.1NP_001290405.1  casein kinase II subunit beta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains multiple differences in the 5' UTR and coding region compared to variant 1, including initiation of translation at a downstream start codon. It encodes isoform 3, which is longer than isoform 1 and has a shorter N-terminus and a distinct C-terminus.
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS79541.1
    UniProtKB/TrEMBL
    G3UZX4
    Related
    ENSMUSP00000134673.2, ENSMUST00000174024.8
    Conserved Domains (1) summary
    smart01085
    Location:8129
    CK_II_beta; Casein kinase II regulatory subunit
  4. NM_009975.3NP_034105.1  casein kinase II subunit beta isoform 2

    See identical proteins and their annotated locations for NP_034105.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28684.1
    UniProtKB/Swiss-Prot
    P67871, Q3TTJ7
    UniProtKB/TrEMBL
    N0E4C0
    Related
    ENSMUSP00000025246.7, ENSMUST00000025246.13
    Conserved Domains (1) summary
    smart01085
    Location:8191
    CK_II_beta; Casein kinase II regulatory subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35335171..35341029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)