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Csnk2a2 casein kinase 2, alpha prime polypeptide [ Mus musculus (house mouse) ]

Gene ID: 13000, updated on 1-Mar-2024

Summary

Official Symbol
Csnk2a2provided by MGI
Official Full Name
casein kinase 2, alpha prime polypeptideprovided by MGI
Primary source
MGI:MGI:88547
See related
Ensembl:ENSMUSG00000046707 AllianceGenome:MGI:88547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CK2; 1110035J23Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within protein phosphorylation and regulation of cell cycle. Predicted to be located in acrosomal vesicle; chromatin; and plasma membrane. Predicted to be part of PcG protein complex and protein kinase CK2 complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study male infertility. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.5), CNS E11.5 (RPKM 7.2) and 27 other tissues See more
Orthologs
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Genomic context

See Csnk2a2 in Genome Data Viewer
Location:
8 C5- D1; 8 47.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96172724..96215505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95446096..95488868, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 15 Neighboring gene VISTA enhancer mm71 Neighboring gene STARR-positive B cell enhancer ABC_E245 Neighboring gene cilia and flagella associated protein 20 Neighboring gene STARR-seq mESC enhancer starr_22388 Neighboring gene RIKEN cDNA 4933406B17 gene Neighboring gene STARR-seq mESC enhancer starr_22390 Neighboring gene coiled-coil domain containing 113

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein kinase CK2 complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
casein kinase II subunit alpha'
Names
CK II alpha'
casein kinase II, alpha 2, polypeptide
NP_034104.1
XP_006530704.1
XP_006530705.1
XP_006530706.1
XP_030099139.1
XP_036009637.1
XP_036009638.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009974.3NP_034104.1  casein kinase II subunit alpha'

    See identical proteins and their annotated locations for NP_034104.1

    Status: VALIDATED

    Source sequence(s)
    AC165414, AK002927, AK030035, BM963966, CB056745
    Consensus CDS
    CCDS22562.1
    UniProtKB/Swiss-Prot
    O54833
    UniProtKB/TrEMBL
    Q545V8, Q8BPF9
    Related
    ENSMUSP00000055919.8, ENSMUST00000056919.9
    Conserved Domains (1) summary
    cd14132
    Location:22326
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    96172724..96215505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530641.5XP_006530704.1  casein kinase II subunit alpha' isoform X1

    UniProtKB/TrEMBL
    Q8BPF9
    Conserved Domains (1) summary
    cd14132
    Location:22275
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  2. XM_006530643.4XP_006530706.1  casein kinase II subunit alpha' isoform X2

    See identical proteins and their annotated locations for XP_006530706.1

    UniProtKB/TrEMBL
    A0A1D5RM74
    Conserved Domains (1) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  3. XM_006530642.2XP_006530705.1  casein kinase II subunit alpha' isoform X2

    See identical proteins and their annotated locations for XP_006530705.1

    UniProtKB/TrEMBL
    A0A1D5RM74
    Conserved Domains (1) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  4. XM_030243279.2XP_030099139.1  casein kinase II subunit alpha' isoform X2

    UniProtKB/TrEMBL
    A0A1D5RM74
    Related
    ENSMUSP00000148660.2, ENSMUST00000212616.2
    Conserved Domains (1) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  5. XM_036153744.1XP_036009637.1  casein kinase II subunit alpha' isoform X2

    UniProtKB/TrEMBL
    A0A1D5RM74
    Conserved Domains (1) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  6. XM_036153745.1XP_036009638.1  casein kinase II subunit alpha' isoform X2

    UniProtKB/TrEMBL
    A0A1D5RM74
    Conserved Domains (1) summary
    cd14132
    Location:1189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2