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CFAP210 cilia and flagella associated protein 210 [ Homo sapiens (human) ]

Gene ID: 129881, updated on 25-Nov-2025
Official Symbol
CFAP210provided by HGNC
Official Full Name
cilia and flagella associated protein 210provided by HGNC
Primary source
HGNC:HGNC:25064
See related
Ensembl:ENSG00000154479 AllianceGenome:HGNC:25064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2orf77; CCDC173
Summary
Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Restricted expression toward testis (RPKM 36.5) See more
Orthologs
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See CFAP210 in Genome Data Viewer
Location:
2q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169645425..169694405, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170122581..170174007, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170501935..170550915, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr2:170393950-170394098 Neighboring gene FAST kinase domains 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:170429982-170430584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16741 Neighboring gene peptidylprolyl isomerase G Neighboring gene MPRA-validated peak3919 silencer Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene phosphatase, orphan 2 Neighboring gene uncharacterized LOC124906089

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance. Blackburn K, et al. J Proteome Res, 2017 Apr 7. PMID 28282151, Free PMC Article
  2. SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. Gui M, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191189, Free PMC Article
  3. In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. Gao H, et al. Anal Chem, 2022 May 31. PMID 35575683
  4. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath IEA
Inferred from Electronic Annotation
more info
  
is_active_in axonemal B tubule inner sheath ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in axonemal microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in polymeric cytoskeletal fiber IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
cilia- and flagella- associated protein 210
Names
coiled-coil domain containing 173
coiled-coil domain-containing protein 173
protein CFAP210

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085447.2 → NP_001078916.1  cilia- and flagella- associated protein 210

    See identical proteins and their annotated locations for NP_001078916.1

    Status: VALIDATED

    Source sequence(s)
    AC016772, BC117445, BQ432665, CB250451
    Consensus CDS
    CCDS46445.1
    UniProtKB/Swiss-Prot
    Q0VFZ6, Q6PJF6
    UniProtKB/TrEMBL
    B4DX81
    Related
    ENSP00000391504.1, ENST00000447353.6
    Conserved Domains (1) summary
    pfam13868
    Location:148 → 480
    TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    169645425..169694405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443327.1 → XP_047299283.1  cilia- and flagella- associated protein 210 isoform X3

  2. XM_011510590.2 → XP_011508892.1  cilia- and flagella- associated protein 210 isoform X2

    Conserved Domains (1) summary
    pfam13868
    Location:67 → 399
    TPH; Trichohyalin-plectin-homology domain

  3. XM_047443326.1 → XP_047299282.1  cilia- and flagella- associated protein 210 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    170122581..170174007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340497.1 → XP_054196472.1  cilia- and flagella- associated protein 210 isoform X3

  2. XM_054340496.1 → XP_054196471.1  cilia- and flagella- associated protein 210 isoform X2

  3. XM_054340495.1 → XP_054196470.1  cilia- and flagella- associated protein 210 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VFZ6.2 GenPept UniProtKB/Swiss-Prot:Q0VFZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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