CFAP210 cilia and flagella associated protein 210 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CFAP210provided by HGNC
Official Full Name: cilia and flagella associated protein 210provided by HGNC
Primary source: HGNC:HGNC:25064
See related: Ensembl:ENSG00000154479 AllianceGenome:HGNC:25064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C2orf77; CCDC173
Summary: Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Mar 2025]
Expression: Restricted expression toward testis (RPKM 36.5) See more
Orthologs: mouse all
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Genomic context

Location:: 2q31.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (169645425..169694405, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (170122581..170174007, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (170501935..170550915, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A004Q48 (e-PCR)
- UniSTS:59937

SHGC-31767 (e-PCR)
- UniSTS:83317

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axonemal B tubule inner sheath	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axonemal microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in axonemal microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in axonemal microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sperm flagellum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cilia- and flagella- associated protein 210

Names: coiled-coil domain containing 173; coiled-coil domain-containing protein 173; protein CFAP210

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085447.2 → NP_001078916.1 cilia- and flagella- associated protein 210

See identical proteins and their annotated locations for NP_001078916.1

Status: VALIDATED

Source sequence(s)

AC016772, BC117445, BQ432665, CB250451

Consensus CDS

CCDS46445.1

UniProtKB/Swiss-Prot

Q0VFZ6, Q6PJF6

UniProtKB/TrEMBL

B4DX81

Related

ENSP00000391504.1, ENST00000447353.6

Conserved Domains (1) summary

pfam13868
Location:148 → 480

TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

169645425..169694405 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047443327.1 → XP_047299283.1 cilia- and flagella- associated protein 210 isoform X3
XM_011510590.2 → XP_011508892.1 cilia- and flagella- associated protein 210 isoform X2

Conserved Domains (1) summary

pfam13868
Location:67 → 399

TPH; Trichohyalin-plectin-homology domain
XM_047443326.1 → XP_047299282.1 cilia- and flagella- associated protein 210 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

170122581..170174007 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054340497.1 → XP_054196472.1 cilia- and flagella- associated protein 210 isoform X3
XM_054340496.1 → XP_054196471.1 cilia- and flagella- associated protein 210 isoform X2
XM_054340495.1 → XP_054196470.1 cilia- and flagella- associated protein 210 isoform X1