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Csf3 colony stimulating factor 3 (granulocyte) [ Mus musculus (house mouse) ]

Gene ID: 12985, updated on 6-Oct-2024

Summary

Official Symbol
Csf3provided by MGI
Official Full Name
colony stimulating factor 3 (granulocyte)provided by MGI
Primary source
MGI:MGI:1339751
See related
Ensembl:ENSMUSG00000038067 AllianceGenome:MGI:1339751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Csfg; G-CSF; MGI-IG
Summary
Enables granulocyte colony-stimulating factor receptor binding activity. Acts upstream of or within positive regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle lumen and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; dorsal aorta; liver; reproductive system; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including allergic cutaneous vasculitis; artery disease (multiple); ischemia (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human CSF3 (colony stimulating factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 3.1), genital fat pad adult (RPKM 0.7) and 4 other tissues See more
Orthologs
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Genomic context

See Csf3 in Genome Data Viewer
Location:
11 D; 11 62.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98591287..98594457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98700183..98703631)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gasdermin A Neighboring gene STARR-seq mESC enhancer starr_30673 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98543708-98543891 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 Neighboring gene predicted gene, 38985 Neighboring gene mediator complex subunit 24 Neighboring gene predicted gene, 22059 Neighboring gene predicted gene, 31252

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity NAS
Non-traceable Author Statement
more info
PubMed 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables granulocyte colony-stimulating factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables granulocyte colony-stimulating factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in granulocyte colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in granulocyte colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in granulocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
granulocyte colony-stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009971.1NP_034101.1  granulocyte colony-stimulating factor precursor

    See identical proteins and their annotated locations for NP_034101.1

    Status: VALIDATED

    Source sequence(s)
    M13926
    Consensus CDS
    CCDS25360.1
    UniProtKB/Swiss-Prot
    P09920
    UniProtKB/TrEMBL
    Q0VB73, Q3UM22
    Related
    ENSMUSP00000037762.3, ENSMUST00000038886.3
    Conserved Domains (1) summary
    pfam16647
    Location:57205
    GCSF; Granulocyte colony-stimulating factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98591287..98594457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245517.2XP_030101377.1  granulocyte colony-stimulating factor isoform X2

    UniProtKB/TrEMBL
    Q3UM22
    Conserved Domains (1) summary
    pfam16647
    Location:108256
    GCSF; Granulocyte colony-stimulating factor
  2. XM_006532128.5XP_006532191.3  granulocyte colony-stimulating factor isoform X1

    Conserved Domains (1) summary
    pfam16647
    Location:241389
    GCSF; Granulocyte colony-stimulating factor