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RBM45 RNA binding motif protein 45 [ Homo sapiens (human) ]

Gene ID: 129831, updated on 4-Jul-2021

Summary

Official Symbol
RBM45provided by HGNC
Official Full Name
RNA binding motif protein 45provided by HGNC
Primary source
HGNC:HGNC:24468
See related
Ensembl:ENSG00000155636 MIM:608888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRB1; RB-1
Summary
This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]
Expression
Ubiquitous expression in testis (RPKM 3.5), lymph node (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See RBM45 in Genome Data Viewer
Location:
2q31.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (178112409..178129656)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (178977164..178994383)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene RNA, U6 small nuclear 629, pseudogene Neighboring gene cytochrome c, testis, pseudogene Neighboring gene RNA, U5E small nuclear 9, pseudogene Neighboring gene oxysterol binding protein like 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies two new risk loci for Graves' disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44612, MGC42237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 45
Names
developmentally regulated RNA-binding protein 1
putative RNA binding protein RB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365578.1NP_001352507.1  RNA-binding protein 45 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011238, BC066549, BI763677
    Conserved Domains (4) summary
    cd12366
    Location:23104
    RRM1_RBM45; RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:120193
    RRM2_RBM45; RNA recognition motif 2 (RRM2) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:246318
    RRM3_RBM45; RNA recognition motif 3 (RRM3) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:391458
    RRM4_RBM45; RNA recognition motif 4 (RRM4) found in RNA-binding protein 45 (RBM45) and similar proteins
  2. NM_001365579.1NP_001352508.1  RNA-binding protein 45 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB036991, BC066549, BI763677
    Related
    ENSP00000482083.1, ENST00000616198.4
    Conserved Domains (4) summary
    cd12366
    Location:23104
    RRM1_RBM45; RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:120193
    RRM2_RBM45; RNA recognition motif 2 (RRM2) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:248320
    RRM3_RBM45; RNA recognition motif 3 (RRM3) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:393460
    RRM4_RBM45; RNA recognition motif 4 (RRM4) found in RNA-binding protein 45 (RBM45) and similar proteins
  3. NM_152945.4NP_694453.2  RNA-binding protein 45 isoform 1

    See identical proteins and their annotated locations for NP_694453.2

    Status: REVIEWED

    Source sequence(s)
    BC066549, BI763677
    Consensus CDS
    CCDS33335.1
    UniProtKB/Swiss-Prot
    Q8IUH3
    Related
    ENSP00000286070.5, ENST00000286070.10
    Conserved Domains (4) summary
    cd12366
    Location:23104
    RRM1_RBM45; RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:120193
    RRM2_RBM45; RNA recognition motif 2 (RRM2) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:246318
    RRM3_RBM45; RNA recognition motif 3 (RRM3) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:391458
    RRM4_RBM45; RNA recognition motif 4 (RRM4) found in RNA-binding protein 45 (RBM45) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    178112409..178129656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003321.1XP_016858810.1  RNA-binding protein 45 isoform X1

    Conserved Domains (5) summary
    TIGR01628
    Location:41206
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12366
    Location:23101
    RRM1_RBM45; RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:263336
    RRM2_RBM45; RNA recognition motif 2 (RRM2) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:389461
    RRM3_RBM45; RNA recognition motif 3 (RRM3) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:534601
    RRM4_RBM45; RNA recognition motif 4 (RRM4) found in RNA-binding protein 45 (RBM45) and similar proteins
  2. XM_017003320.1XP_016858809.1  RNA-binding protein 45 isoform X1

    Conserved Domains (5) summary
    TIGR01628
    Location:41206
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12366
    Location:23101
    RRM1_RBM45; RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12367
    Location:263336
    RRM2_RBM45; RNA recognition motif 2 (RRM2) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12368
    Location:389461
    RRM3_RBM45; RNA recognition motif 3 (RRM3) found in RNA-binding protein 45 (RBM45) and similar proteins
    cd12369
    Location:534601
    RRM4_RBM45; RNA recognition motif 4 (RRM4) found in RNA-binding protein 45 (RBM45) and similar proteins
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