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Csf2 colony stimulating factor 2 (granulocyte-macrophage) [ Mus musculus (house mouse) ]

Gene ID: 12981, updated on 25-Nov-2021

Summary

Official Symbol
Csf2provided by MGI
Official Full Name
colony stimulating factor 2 (granulocyte-macrophage)provided by MGI
Primary source
MGI:MGI:1339752
See related
Ensembl:ENSMUSG00000018916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSF; Csfgm; GMCSF; Gm-CSf; MGI-IGM
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Csf2 in Genome Data Viewer
Location:
11 B1.3; 11 32.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54138096..54140725, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54247270..54249899, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54060772..54063401, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene Sdccag3 pseudogene Neighboring gene RIKEN cDNA 4933405E24 gene Neighboring gene acyl-CoA-binding protein ACBP pseudogene Neighboring gene interleukin 3 Neighboring gene predicted gene, 51861

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC151255, MGC151257

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables granulocyte macrophage colony-stimulating factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial fluid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in granulocyte-macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myeloid cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within myeloid dendritic cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-23 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of granulocyte macrophage colony-stimulating factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
granulocyte-macrophage colony-stimulating factor
Names
colony-stimulating factor
granulocyte-macrophage colony stimulating factor 2
put. GM-CSF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009969.4NP_034099.2  granulocyte-macrophage colony-stimulating factor precursor

    See identical proteins and their annotated locations for NP_034099.2

    Status: VALIDATED

    Source sequence(s)
    AL596103
    Consensus CDS
    CCDS24692.1
    UniProtKB/Swiss-Prot
    P01587
    UniProtKB/TrEMBL
    Q5SX78
    Related
    ENSMUSP00000019060.6, ENSMUST00000019060.6
    Conserved Domains (1) summary
    smart00040
    Location:18135
    CSF2; Granulocyte-macrophage colony-simulating factor (GM-CSF)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54138096..54140725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532127.4XP_006532190.1  granulocyte-macrophage colony-stimulating factor isoform X1

    Conserved Domains (1) summary
    cl23816
    Location:1990
    CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...
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