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Csf1r colony stimulating factor 1 receptor [ Mus musculus (house mouse) ]

Gene ID: 12978, updated on 31-Jan-2023

Summary

Official Symbol
Csf1rprovided by MGI
Official Full Name
colony stimulating factor 1 receptorprovided by MGI
Primary source
MGI:MGI:1339758
See related
Ensembl:ENSMUSG00000024621 AllianceGenome:MGI:1339758
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R
Summary
Enables several functions, including macrophage colony-stimulating factor receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including nervous system development; positive regulation of protein phosphorylation; and protein phosphorylation. Located in cell surface and plasma membrane. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia and renal cell carcinoma. Orthologous to human CSF1R (colony stimulating factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 69.7), placenta adult (RPKM 34.8) and 23 other tissues See more
Orthologs
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Genomic context

See Csf1r in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61238644..61264211)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61105572..61131139)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351 Neighboring gene platelet derived growth factor receptor, beta polypeptide Neighboring gene Csf1r promoter/intronic regulatory region Neighboring gene microRNA 6983 Neighboring gene HMG box domain containing 3 Neighboring gene predicted gene, 26403 Neighboring gene predicted gene, 50614

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables macrophage colony-stimulating factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables macrophage colony-stimulating factor receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables macrophage colony-stimulating factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables macrophage colony-stimulating factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell junction maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to macrophage colony-stimulating factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in dentate gyrus development ISO
Inferred from Sequence Orthology
more info
 
involved_in forebrain neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage colony-stimulating factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglia development ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of myotube differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet formation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation by host of viral process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of leukocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ruffle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CSF1-CSF1R complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CSF1-CSF1R complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
macrophage colony-stimulating factor 1 receptor
Names
CSF-1 receptor
CSF-1-R
c-fms
proto-oncogene c-Fms
proto-oncogene fms
NP_001032948.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037859.2NP_001032948.2  macrophage colony-stimulating factor 1 receptor precursor

    See identical proteins and their annotated locations for NP_001032948.2

    Status: VALIDATED

    Source sequence(s)
    AK146069, BB738990, BC066863
    Consensus CDS
    CCDS29280.1
    UniProtKB/Swiss-Prot
    P09581, Q9DBH9
    UniProtKB/TrEMBL
    Q0P635, Q3UKC6, Q6NXV8
    Related
    ENSMUSP00000025523.7, ENSMUST00000025523.13
    Conserved Domains (6) summary
    cd05106
    Location:541913
    PTKc_CSF-1R; Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor
    smart00409
    Location:28101
    IG; Immunoglobulin
    smart00410
    Location:113195
    IG_like; Immunoglobulin like
    pfam13927
    Location:399487
    Ig_3; Immunoglobulin domain
    cd00096
    Location:203208
    Ig; Ig strand A [structural motif]
    cl11960
    Location:203295
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61238644..61264211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007779.2: Suppressed sequence

    Description
    NM_007779.2: This RefSeq was permanently suppressed because currently insufficient support exists for the transcript and the protein.