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Csf1 colony stimulating factor 1 (macrophage) [ Mus musculus (house mouse) ]

Gene ID: 12977, updated on 25-Jan-2022

Summary

Official Symbol
Csf1provided by MGI
Official Full Name
colony stimulating factor 1 (macrophage)provided by MGI
Primary source
MGI:MGI:1339753
See related
Ensembl:ENSMUSG00000014599 AllianceGenome:MGI:1339753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
op; Csfm; MCSF; C87615
Summary
Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in spleen adult (RPKM 14.8), mammary gland adult (RPKM 13.9) and 28 other tissues See more
Orthologs
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Genomic context

See Csf1 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107648364..107668048, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107741048..107760469, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (107543966..107563387, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10961 Neighboring gene S-adenosylhomocysteine hydrolase-like 1 Neighboring gene predicted gene, 52629 Neighboring gene predicted gene, 40121 Neighboring gene uncharacterized LOC118568636 Neighboring gene 60S ribosomal protein L13-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables macrophage colony-stimulating factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in developmental process involved in reproduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage colony-stimulating factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary duct terminal end bud growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland fat development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoclast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microglial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mononuclear cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CSF1-CSF1R complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
macrophage colony-stimulating factor 1
Names
osteopetrosis
NP_001107001.1
NP_001107002.1
NP_031804.3
XP_036018771.1
XP_036018772.1
XP_036018773.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113529.1NP_001107001.1  macrophage colony-stimulating factor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001107001.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC140786, AI844210, S78392
    Consensus CDS
    CCDS51044.1
    UniProtKB/Swiss-Prot
    P07141
    Related
    ENSMUSP00000113136.2, ENSMUST00000118593.8
    Conserved Domains (1) summary
    pfam05337
    Location:1257
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
  2. NM_001113530.1NP_001107002.1  macrophage colony-stimulating factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001107002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AC140786, CA328312, X05010
    Consensus CDS
    CCDS17740.1
    UniProtKB/Swiss-Prot
    P07141
    Related
    ENSMUSP00000113617.2, ENSMUST00000120243.8
    Conserved Domains (1) summary
    pfam05337
    Location:275552
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
  3. NM_007778.4NP_031804.3  macrophage colony-stimulating factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031804.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AC140786, AI844210, AK160995, BC066187
    Consensus CDS
    CCDS17740.1
    UniProtKB/Swiss-Prot
    P07141
    Related
    ENSMUSP00000014743.4, ENSMUST00000014743.10
    Conserved Domains (1) summary
    pfam05337
    Location:275552
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    107648364..107668048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162880.1XP_036018773.1  macrophage colony-stimulating factor 1 isoform X2

    Conserved Domains (1) summary
    pfam05337
    Location:65204
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
  2. XM_036162878.1XP_036018771.1  macrophage colony-stimulating factor 1 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:220496
    PHA03247; large tegument protein UL36; Provisional
    pfam05337
    Location:65204
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
  3. XM_036162879.1XP_036018772.1  macrophage colony-stimulating factor 1 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:220496
    PHA03247; large tegument protein UL36; Provisional
    pfam05337
    Location:65204
    CSF-1; Macrophage colony stimulating factor-1 (CSF-1)
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