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Cs citrate synthase [ Mus musculus (house mouse) ]

Gene ID: 12974, updated on 8-Feb-2024

Summary

Official Symbol
Csprovided by MGI
Official Full Name
citrate synthaseprovided by MGI
Primary source
MGI:MGI:88529
See related
Ensembl:ENSMUSG00000005683 AllianceGenome:MGI:88529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cis; Ahl4; 2610511A05Rik; 9030605P22Rik
Summary
The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in heart adult (RPKM 476.6), large intestine adult (RPKM 212.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 D3; 10 76.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128173596..128198351)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128337727..128362482)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene predicted gene, 23182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127806017-127806126 Neighboring gene coenzyme Q10A Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA 6914

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer IDA
Inferred from Direct Assay
more info
PubMed 
enables citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables citrate (Si)-synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables citrate (Si)-synthase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables citrate (Si)-synthase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in citrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
citrate synthase, mitochondrial
Names
citrate (Si)-synthase
NP_080720.1
XP_030100721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026444.4NP_080720.1  citrate synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_080720.1

    Status: REVIEWED

    Source sequence(s)
    AC090489, BU700437, CJ144772
    Consensus CDS
    CCDS24273.1
    UniProtKB/Swiss-Prot
    Q3UDP3, Q9CZU6
    UniProtKB/TrEMBL
    Q9DAM4
    Related
    ENSMUSP00000005826.8, ENSMUST00000005826.9
    Conserved Domains (2) summary
    cd06105
    Location:33459
    ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
    PLN02456
    Location:29454
    PLN02456; citrate synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128173596..128198351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244861.1XP_030100721.1  citrate synthase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q9DAM4
    Conserved Domains (1) summary
    cd06105
    Location:1393
    ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...