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TAF8 TATA-box binding protein associated factor 8 [ Homo sapiens (human) ]

Gene ID: 129685, updated on 17-Jun-2024

Summary

Official Symbol
TAF8provided by HGNC
Official Full Name
TATA-box binding protein associated factor 8provided by HGNC
Primary source
HGNC:HGNC:17300
See related
Ensembl:ENSG00000137413 MIM:609514; AllianceGenome:HGNC:17300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
II; TAF; TBN; NEDMLHB; TAFII43; TAFII-43; TAF(II)43
Summary
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See TAF8 in Genome Data Viewer
Location:
6p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42050524..42087462)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41878783..41915706)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42018262..42051010)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:41884515-41885714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41892998-41893498 Neighboring gene mediator complex subunit 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41906017-41906832 Neighboring gene bystin like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41906833-41907648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41908777-41909728 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:41928638-41928835 Neighboring gene cyclin D3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:41932711-41933221 Neighboring gene uncharacterized LOC105375059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41976875-41977831 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41977832-41978787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41984389-41984890 Neighboring gene Sharpr-MPRA regulatory regions 12575 and 14060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24534 Neighboring gene RNA, U6 small nuclear 761, pseudogene Neighboring gene skeletal muscle cis-regulatory module in CCND3 intron Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42007359-42007580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42011196-42011696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24537 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42013050-42013640 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42013641-42014230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17197 Neighboring gene H3K27ac hESC enhancers GRCh37_chr6:42017885-42018436 and GRCh37_chr6:42018437-42018988 Neighboring gene Sharpr-MPRA regulatory region 7068 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:42067953-42068174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17200 Neighboring gene chromosome 6 open reading frame 132 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42104000-42104697 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42108933-42109612 Neighboring gene GUCA1ANB-GUCA1A readthrough Neighboring gene ciliary microtubule inner protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ32821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IC
Inferred by Curator
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus EXP
Inferred from Experiment
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIID complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 8
Names
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa
TBP-associated factor 43 kDa
TBP-associated factor 8
TBP-associated factor TAFII43
TBP-associated factor, RNA polymerase II, 43 kD
hTAFII43
protein taube nuss
taube nuss homolog
transcription initiation factor TFIID 43 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410906.1NP_001397835.1  transcription initiation factor TFIID subunit 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL512274, AL513008
    Consensus CDS
    CCDS93918.1
    UniProtKB/TrEMBL
    A0A8I5KVM3, A0A8I5QL44
    Related
    ENSP00000510786.1, ENST00000686229.1
  2. NM_001410907.1NP_001397836.1  transcription initiation factor TFIID subunit 8 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL512274, AL513008
    Consensus CDS
    CCDS93919.1
    UniProtKB/TrEMBL
    A0A8I5KVM3
    Related
    ENSP00000411900.2, ENST00000456846.6
  3. NM_138572.3NP_612639.2  transcription initiation factor TFIID subunit 8 isoform 1

    See identical proteins and their annotated locations for NP_612639.2

    Status: REVIEWED

    Source sequence(s)
    AF465841, AL512274, BI828714
    Consensus CDS
    CCDS43462.1
    UniProtKB/Swiss-Prot
    Q5T0K1, Q7Z7C8, Q8N4R9, Q96M52
    UniProtKB/TrEMBL
    A0A8I5KVM3
    Related
    ENSP00000362068.3, ENST00000372977.8
    Conserved Domains (2) summary
    cd08049
    Location:144197
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:29106
    Bromo_TP; Bromodomain associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42050524..42087462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418177.1XP_047274133.1  transcription initiation factor TFIID subunit 8 isoform X2

  2. XM_047418174.1XP_047274130.1  transcription initiation factor TFIID subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVM3
    Related
    ENSP00000362073.4, ENST00000372982.8
  3. XM_047418178.1XP_047274134.1  transcription initiation factor TFIID subunit 8 isoform X4

  4. XM_017010245.2XP_016865734.1  transcription initiation factor TFIID subunit 8 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXI2
    Related
    ENSP00000510369.1, ENST00000687601.1
  5. XM_017010244.3XP_016865733.1  transcription initiation factor TFIID subunit 8 isoform X3

  6. XM_047418175.1XP_047274131.1  transcription initiation factor TFIID subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVM3
    Related
    ENSP00000417867.1, ENST00000494547.5
  7. XM_005248849.3XP_005248906.1  transcription initiation factor TFIID subunit 8 isoform X6

    UniProtKB/TrEMBL
    A0A0A0MRR3
    Related
    ENSP00000362069.3, ENST00000372978.7
    Conserved Domains (2) summary
    pfam07524
    Location:29106
    Bromo_TP; Bromodomain associated
    pfam10406
    Location:145163
    TAF8_C; Transcription factor TFIID complex subunit 8 C-term

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41878783..41915706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354207.1XP_054210182.1  transcription initiation factor TFIID subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVM3
  2. XM_054354211.1XP_054210186.1  transcription initiation factor TFIID subunit 8 isoform X4

  3. XM_054354212.1XP_054210187.1  transcription initiation factor TFIID subunit 8 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXI2
  4. XM_054354210.1XP_054210185.1  transcription initiation factor TFIID subunit 8 isoform X3

  5. XM_054354208.1XP_054210183.1  transcription initiation factor TFIID subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5KVM3
  6. XM_054354213.1XP_054210188.1  transcription initiation factor TFIID subunit 8 isoform X6

    UniProtKB/TrEMBL
    A0A0A0MRR3
  7. XM_054354209.1XP_054210184.1  transcription initiation factor TFIID subunit 8 isoform X2