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TAF8 TATA-box binding protein associated factor 8 [ Homo sapiens (human) ]

Gene ID: 129685, updated on 12-Oct-2019

Summary

Official Symbol
TAF8provided by HGNC
Official Full Name
TATA-box binding protein associated factor 8provided by HGNC
Primary source
HGNC:HGNC:17300
See related
Ensembl:ENSG00000137413 MIM:609514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
II; TAF; TBN; TAFII43; TAFII-43; TAF(II)43
Summary
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See TAF8 in Genome Data Viewer
Location:
6p21.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (42050522..42083278)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42018251..42055093)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene Sharpr-MPRA regulatory regions 12575 and 14060 Neighboring gene skeletal muscle cis-regulatory module in CCND3 intron Neighboring gene chromosome 6 open reading frame 132 Neighboring gene Uncharacterized protein 114841037 Neighboring gene guanylate cyclase activator 1A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription initiation factor TFIID subunit 8
Names
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDa
TBP-associated factor 43 kDa
TBP-associated factor 8
TBP-associated factor TAFII43
TBP-associated factor, RNA polymerase II, 43 kD
hTAFII43
protein taube nuss
taube nuss homolog
transcription initiation factor TFIID 43 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138572.3NP_612639.2  transcription initiation factor TFIID subunit 8

    See identical proteins and their annotated locations for NP_612639.2

    Status: REVIEWED

    Source sequence(s)
    AF465841, AL512274, BI828714
    Consensus CDS
    CCDS43462.1
    UniProtKB/Swiss-Prot
    Q7Z7C8
    Related
    ENSP00000362068.3, ENST00000372977.8
    Conserved Domains (2) summary
    cd08049
    Location:144197
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:29106
    Bromo_TP; Bromodomain associated

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    42050522..42083278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010241.2XP_016865730.1  transcription initiation factor TFIID subunit 8 isoform X2

    Related
    ENSP00000411900.2, ENST00000456846.6
  2. XM_011514296.2XP_011512598.1  transcription initiation factor TFIID subunit 8 isoform X1

    See identical proteins and their annotated locations for XP_011512598.1

    UniProtKB/Swiss-Prot
    Q7Z7C8
    Related
    ENSP00000417867.1, ENST00000494547.5
    Conserved Domains (3) summary
    cd08049
    Location:144197
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:29106
    Bromo_TP; Bromodomain associated
    pfam13900
    Location:266303
    GVQW; Putative domain of unknown function
  3. XM_017010244.2XP_016865733.1  transcription initiation factor TFIID subunit 8 isoform X5

  4. XM_017010245.1XP_016865734.1  transcription initiation factor TFIID subunit 8 isoform X6

  5. XM_005248849.2XP_005248906.1  transcription initiation factor TFIID subunit 8 isoform X7

    Related
    ENSP00000362069.3, ENST00000372978.7
    Conserved Domains (2) summary
    pfam07524
    Location:29106
    Bromo_TP; Bromodomain associated
    pfam10406
    Location:145163
    TAF8_C; Transcription factor TFIID complex subunit 8 C-term
  6. XM_017010242.2XP_016865731.1  transcription initiation factor TFIID subunit 8 isoform X3

  7. XM_017010243.2XP_016865732.1  transcription initiation factor TFIID subunit 8 isoform X4

    Related
    ENSP00000418029.1, ENST00000465926.5
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