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MBOAT2 membrane bound O-acyltransferase domain containing 2 [ Homo sapiens (human) ]

Gene ID: 129642, updated on 22-Sep-2022

Summary

Official Symbol
MBOAT2provided by HGNC
Official Full Name
membrane bound O-acyltransferase domain containing 2provided by HGNC
Primary source
HGNC:HGNC:25193
See related
Ensembl:ENSG00000143797 MIM:611949; AllianceGenome:HGNC:25193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPAAT; LPCAT; LPEAT; OACT2; LPCAT4; LPLAT 2; LPLAT13
Summary
Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 14.5), brain (RPKM 13.4) and 23 other tissues See more
Orthologs
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Genomic context

See MBOAT2 in Genome Data Viewer
Location:
2p25.1
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8852690..9003684, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8876443..9027457, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8992820..9143813, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene kinase D interacting substrate 220 Neighboring gene ADP ribosylation factor like GTPase 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5743 Neighboring gene Sharpr-MPRA regulatory region 138 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 6065 Neighboring gene uncharacterized LOC124907728 Neighboring gene high mobility group box 1 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14415, FLJ90298

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lysophospholipid acyltransferase 2
Names
1-acylglycerophosphate O-acyltransferase
1-acylglycerophosphate O-acyltransferase MBOAT2
1-acylglycerophosphocholine O-acyltransferase MBOAT2
1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase
1-acylglycerophosphoethanolamine O-acyltransferase
O-acyltransferase (membrane bound) domain containing 2
lyso-PA acyltransferase
lyso-PC acyltransferase
lyso-PC acyltransferase 4
lyso-PE acyltransferase
lysophosphatidic acid acyltransferase
lysophosphatidylcholine acyltransferase
lysophosphatidylcholine acyltransferase 4
lysophosphatidylethanolamine acyltransferase
lysophospholipid acyltransferase 13
membrane-bound O-acyltransferase domain-containing protein 2
NP_001308194.1
NP_001308195.1
NP_001308196.1
NP_620154.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321265.2NP_001308194.1  lysophospholipid acyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/Swiss-Prot
    Q6ZWT7
    UniProtKB/TrEMBL
    B0AZU0
    Conserved Domains (1) summary
    cl00738
    Location:14361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  2. NM_001321266.2NP_001308195.1  lysophospholipid acyltransferase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/Swiss-Prot
    Q6ZWT7
    Conserved Domains (1) summary
    cl00738
    Location:1317
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  3. NM_001321267.2NP_001308196.1  lysophospholipid acyltransferase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    UniProtKB/Swiss-Prot
    Q6ZWT7
    UniProtKB/TrEMBL
    B0AZU0, B7Z3I3
    Conserved Domains (1) summary
    cl00738
    Location:14361
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
  4. NM_138799.4NP_620154.2  lysophospholipid acyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_620154.2

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
    Consensus CDS
    CCDS1660.1
    UniProtKB/Swiss-Prot
    Q6ZWT7, Q96KY4
    Related
    ENSP00000302177.3, ENST00000305997.8
    Conserved Domains (1) summary
    cl00738
    Location:13450
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

RNA

  1. NR_135598.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  2. NR_135599.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  3. NR_135600.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  4. NR_135601.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  5. NR_135602.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  6. NR_135603.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  7. NR_135604.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  8. NR_135605.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723
  9. NR_135606.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012495, AC112723

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    8852690..9003684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    8876443..9027457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)