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NMS neuromedin S [ Homo sapiens (human) ]

Gene ID: 129521, updated on 13-May-2022

Summary

Official Symbol
NMSprovided by HGNC
Official Full Name
neuromedin Sprovided by HGNC
Primary source
HGNC:HGNC:32203
See related
Ensembl:ENSG00000204640 MIM:619337; AllianceGenome:HGNC:32203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the neuromedin family of neuropeptides. The encoded preproprotein is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. [provided by RefSeq, May 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See NMS in Genome Data Viewer
Location:
2q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (100470482..100483280)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (100929252..100942050)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101086944..101099742)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 10 Neighboring gene RALBP1 pseudogene 2 Neighboring gene uncharacterized LOC105373506 Neighboring gene ARPP19 pseudogene 2 Neighboring gene phosducin like 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in locomotor rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
neuromedin-S
Names
neuromedin S precursor-related peptide/neuromedin S preproprotein
prepro-NMS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011717.1NP_001011717.1  neuromedin-S preproprotein

    See identical proteins and their annotated locations for NP_001011717.1

    Status: REVIEWED

    Source sequence(s)
    AB164464
    Consensus CDS
    CCDS33259.1
    UniProtKB/Swiss-Prot
    Q5H8A3
    UniProtKB/TrEMBL
    A0A250SI41
    Related
    ENSP00000366061.1, ENST00000376865.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    100470482..100483280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    100929252..100942050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)