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Cr1l complement C3b/C4b receptor 1 like [ Mus musculus (house mouse) ]

Gene ID: 12946, updated on 5-Mar-2024

Summary

Official Symbol
Cr1lprovided by MGI
Official Full Name
complement C3b/C4b receptor 1 likeprovided by MGI
Primary source
MGI:MGI:88513
See related
Ensembl:ENSMUSG00000016481 AllianceGenome:MGI:88513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcp; Crry; mCRY
Summary
Predicted to enable complement receptor activity and opsonin binding activity. Acts upstream of or within several processes, including cellular response to hypoxia; complement activation; and negative regulation of complement activation. Located in basolateral plasma membrane and external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in malaria. Orthologous to several human genes including CR1L (complement C3b/C4b receptor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 23.9), placenta adult (RPKM 23.8) and 28 other tissues See more
Orthologs
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Genomic context

See Cr1l in Genome Data Viewer
Location:
1 H6; 1 98.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (194781019..194813878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (195098711..195131570, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330023F24 gene Neighboring gene microRNA 29b-2 Neighboring gene STARR-seq mESC enhancer starr_03503 Neighboring gene microRNA 29c Neighboring gene CD46 antigen, complement regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E11117 Neighboring gene STARR-seq mESC enhancer starr_03504 Neighboring gene predicted gene, 32313 Neighboring gene complement receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E11118 Neighboring gene predicted gene, 29726

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC102484

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables complement component C3b binding ISO
Inferred from Sequence Orthology
more info
 
enables complement component C3b receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables complement component C4b binding ISO
Inferred from Sequence Orthology
more info
 
enables complement component C4b receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within female pregnancy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of complement activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of complement activation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of complement activation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
complement component receptor 1-like protein
Names
complement component (3b/4b) receptor 1-like
complement receptor related protein
complement regulatory protein Crry
protein p65

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355060.1NP_001341989.1  complement component receptor 1-like protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC139206, AK134226
    Consensus CDS
    CCDS87948.1
    UniProtKB/Swiss-Prot
    E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
    UniProtKB/TrEMBL
    A0A0A6YY75
    Related
    ENSMUSP00000142309.2, ENSMUST00000193094.6
    Conserved Domains (1) summary
    cl27761
    Location:42295
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. NM_001355061.1NP_001341990.1  complement component receptor 1-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139206, AK160440
    Consensus CDS
    CCDS87947.1
    UniProtKB/TrEMBL
    A0A0A6YXN9
    Related
    ENSMUSP00000142069.2, ENSMUST00000194111.6
    Conserved Domains (1) summary
    cl27761
    Location:4257
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  3. NM_013499.2NP_038527.2  complement component receptor 1-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_038527.2

    Status: VALIDATED

    Source sequence(s)
    AI098173, AK004825, CA491482
    Consensus CDS
    CCDS15641.1
    UniProtKB/Swiss-Prot
    E9QL18, Q3TV30, Q58E68, Q61447, Q61449, Q64735, Q8CF59, Q8K328
    Related
    ENSMUSP00000074902.7, ENSMUST00000075451.12
    Conserved Domains (4) summary
    cd00033
    Location:165232
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:237293
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:42295
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:4298
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    194781019..194813878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)