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Dmbt1 deleted in malignant brain tumors 1 [ Mus musculus (house mouse) ]

Gene ID: 12945, updated on 9-Sep-2018

Summary

Official Symbol
Dmbt1provided by MGI
Official Full Name
deleted in malignant brain tumors 1provided by MGI
Primary source
MGI:MGI:106210
See related
Ensembl:ENSMUSG00000047517 Vega:OTTMUSG00000059749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRP; p80; Crpd; DBMT1; gp300; CRP-[a]; CRP-[b]
Annotation information
Note: There are conflicting opinions about the protein-coding potential of this locus. [17 Jun 2011]
Expression
Biased expression in colon adult (RPKM 494.9), large intestine adult (RPKM 367.0) and 4 other tissues See more
Orthologs

Genomic context

See Dmbt1 in Genome Data Viewer
Location:
7; 7 F3
Exon count:
51
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (131032060..131121628)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (138175590..138265142)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Neighboring gene microRNA 7061 Neighboring gene HtrA serine peptidase 1 Neighboring gene RIKEN cDNA 4933402N03 gene Neighboring gene RIKEN cDNA 1700029B22 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
zymogen binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
inner cell mass cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
zymogen granule membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deleted in malignant brain tumors 1 protein
Names
apactin
crp-ductin
deleted in malignant brain tumors 1 pseudogene
ebnerin
glycoprotein 300
hensin
mucin-like glycoprotein
muclin
vomeroglandin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347632.1NP_001334561.1  deleted in malignant brain tumors 1 protein isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB005909, AC087063
    Consensus CDS
    CCDS85436.1
    UniProtKB/Swiss-Prot
    Q60997
  2. NM_007769.2NP_031795.2  deleted in malignant brain tumors 1 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_031795.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC049835
    Consensus CDS
    CCDS21909.1
    UniProtKB/Swiss-Prot
    Q60997
    Related
    ENSMUSP00000081556.3, OTTMUSP00000076250, ENSMUST00000084509.4, OTTMUST00000146457
    Conserved Domains (5) summary
    smart00202
    Location:324424
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:16131860
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14941602
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17311858
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13761471
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    131032060..131121628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507307.3XP_006507370.1  deleted in malignant brain tumors 1 protein isoform X10

    Conserved Domains (3) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    cd00041
    Location:9991107
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00530
    Location:583678
    SRCR; Scavenger receptor cysteine-rich domain
  2. XM_006507302.3XP_006507365.1  deleted in malignant brain tumors 1 protein isoform X5

    Conserved Domains (5) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17281975
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:16091717
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:18461973
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:14911586
    SRCR; Scavenger receptor cysteine-rich domain
  3. XM_006507298.3XP_006507361.1  deleted in malignant brain tumors 1 protein isoform X1

    Conserved Domains (5) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17281975
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:16091717
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:18461973
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:14911586
    SRCR; Scavenger receptor cysteine-rich domain
  4. XM_006507299.3XP_006507362.1  deleted in malignant brain tumors 1 protein isoform X2

    Conserved Domains (5) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17181965
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15991707
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:18361963
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:14811576
    SRCR; Scavenger receptor cysteine-rich domain
  5. XM_006507304.3XP_006507367.1  deleted in malignant brain tumors 1 protein isoform X7

    Conserved Domains (5) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:16021849
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14831591
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17201847
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13651460
    SRCR; Scavenger receptor cysteine-rich domain
  6. XM_006507306.3XP_006507369.1  deleted in malignant brain tumors 1 protein isoform X9

    Related
    ENSMUSP00000148657.1, OTTMUSP00000078430, ENSMUST00000213064.1, OTTMUST00000151232
    Conserved Domains (5) summary
    smart00202
    Location:439539
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:15891836
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14701578
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17071834
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13521447
    SRCR; Scavenger receptor cysteine-rich domain
  7. XM_006507301.3XP_006507364.1  deleted in malignant brain tumors 1 protein isoform X4

    Conserved Domains (5) summary
    smart00202
    Location:428528
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17171964
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15981706
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:18351962
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:14801575
    SRCR; Scavenger receptor cysteine-rich domain
  8. XM_006507305.3XP_006507368.1  deleted in malignant brain tumors 1 protein isoform X8

    Conserved Domains (5) summary
    smart00202
    Location:718818
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:15901837
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:14711579
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17081835
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13531448
    SRCR; Scavenger receptor cysteine-rich domain
  9. XM_006507300.3XP_006507363.1  deleted in malignant brain tumors 1 protein isoform X3

    Conserved Domains (5) summary
    smart00202
    Location:428528
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:17171964
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15981706
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:18351962
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:14801575
    SRCR; Scavenger receptor cysteine-rich domain
  10. XM_006507303.3XP_006507366.1  deleted in malignant brain tumors 1 protein isoform X6

    Related
    ENSMUSP00000146685.1, OTTMUSP00000076268, ENSMUST00000208311.1, OTTMUST00000146510
    Conserved Domains (5) summary
    smart00202
    Location:335435
    SR; Scavenger receptor Cys-rich
    smart00241
    Location:16241871
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:15051613
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:17421869
    Zona_pellucida; Zona pellucida-like domain
    pfam00530
    Location:13871482
    SRCR; Scavenger receptor cysteine-rich domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019334.1: Suppressed sequence

    Description
    NG_019334.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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