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TMEM150A transmembrane protein 150A [ Homo sapiens (human) ]

Gene ID: 129303, updated on 11-Jun-2021

Summary

Official Symbol
TMEM150Aprovided by HGNC
Official Full Name
transmembrane protein 150Aprovided by HGNC
Primary source
HGNC:HGNC:24677
See related
Ensembl:ENSG00000168890 MIM:616757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTN1; TM6P1; TMEM150
Expression
Ubiquitous expression in placenta (RPKM 10.3), kidney (RPKM 7.9) and 24 other tissues See more
Orthologs
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Genomic context

See TMEM150A in Genome Data Viewer
Location:
2p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (85598547..85602698, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85825670..85829821, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene vesicle associated membrane protein 5 Neighboring gene ring finger protein 181 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene chromosome 2 open reading frame 68 Neighboring gene surfactant protein B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 150A
Names
fasting-inducible integral membrane protein TM6P1
tentonin 1
transmembrane protein 150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031738.3NP_001026908.1  transmembrane protein 150A isoform 1

    See identical proteins and their annotated locations for NP_001026908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW009533, BC050466, DA434376
    Consensus CDS
    CCDS33233.1
    UniProtKB/Swiss-Prot
    Q86TG1
    Related
    ENSP00000334708.5, ENST00000334462.10
    Conserved Domains (1) summary
    pfam10277
    Location:3229
    Frag1; Frag1/DRAM/Sfk1 family
  2. NM_001369917.1NP_001356846.1  transmembrane protein 150A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016753
    Related
    ENSP00000387292.1, ENST00000409668.1
    Conserved Domains (1) summary
    pfam10277
    Location:3229
    Frag1; Frag1/DRAM/Sfk1 family
  3. NM_153342.4NP_699173.2  transmembrane protein 150A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC016753
    Related
    ENSP00000302715.3, ENST00000306353.7
    Conserved Domains (1) summary
    pfam10277
    Location:37176
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    85598547..85602698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003306.1XP_016858795.1  transmembrane protein 150A isoform X3

    Related
    ENST00000444380.5
    Conserved Domains (1) summary
    pfam10277
    Location:20182
    Frag1; Frag1/DRAM/Sfk1 family
  2. XM_006711931.3XP_006711994.1  transmembrane protein 150A isoform X1

    See identical proteins and their annotated locations for XP_006711994.1

    UniProtKB/Swiss-Prot
    Q86TG1
    Conserved Domains (1) summary
    pfam10277
    Location:3229
    Frag1; Frag1/DRAM/Sfk1 family
  3. XM_006711930.3XP_006711993.1  transmembrane protein 150A isoform X1

    See identical proteins and their annotated locations for XP_006711993.1

    UniProtKB/Swiss-Prot
    Q86TG1
    Conserved Domains (1) summary
    pfam10277
    Location:3229
    Frag1; Frag1/DRAM/Sfk1 family
  4. XM_006711932.2XP_006711995.1  transmembrane protein 150A isoform X4

    See identical proteins and their annotated locations for XP_006711995.1

    UniProtKB/Swiss-Prot
    Q86TG1
    Conserved Domains (1) summary
    pfam10277
    Location:37176
    Frag1; Frag1/DRAM/Sfk1 family
  5. XM_011532507.2XP_011530809.1  transmembrane protein 150A isoform X3

    See identical proteins and their annotated locations for XP_011530809.1

    Conserved Domains (1) summary
    pfam10277
    Location:20182
    Frag1; Frag1/DRAM/Sfk1 family
  6. XM_017003305.1XP_016858794.1  transmembrane protein 150A isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:20182
    Frag1; Frag1/DRAM/Sfk1 family
  7. XM_017003307.1XP_016858796.1  transmembrane protein 150A isoform X3

    Conserved Domains (1) summary
    pfam10277
    Location:20182
    Frag1; Frag1/DRAM/Sfk1 family
  8. XM_011532508.2XP_011530810.1  transmembrane protein 150A isoform X4

    See identical proteins and their annotated locations for XP_011530810.1

    UniProtKB/Swiss-Prot
    Q86TG1
    Conserved Domains (1) summary
    pfam10277
    Location:37176
    Frag1; Frag1/DRAM/Sfk1 family
  9. XM_011532505.2XP_011530807.1  transmembrane protein 150A isoform X2

    Conserved Domains (1) summary
    pfam10277
    Location:1205
    Frag1; Frag1/DRAM/Sfk1 family
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