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Crip1 cysteine-rich protein 1 (intestinal) [ Mus musculus (house mouse) ]

Gene ID: 12925, updated on 26-Sep-2022

Summary

Official Symbol
Crip1provided by MGI
Official Full Name
cysteine-rich protein 1 (intestinal)provided by MGI
Primary source
MGI:MGI:88501
See related
Ensembl:ENSMUSG00000006360 AllianceGenome:MGI:88501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRHP; CRP1; Crip
Summary
Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and response to zinc ion. Predicted to be located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; integumental system; and limb segment. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 3684.4), small intestine adult (RPKM 2998.6) and 10 other tissues See more
Orthologs
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Genomic context

See Crip1 in Genome Data Viewer
Location:
12 F1; 12 61.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (113115632..113117499)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (113152012..113153879)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cysteine rich protein 2 Neighboring gene predicted gene, 30599 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene origin of replication downstream of immunoglobulin heavy chain (Igh) locus

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV-B ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cellular response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to antibiotic ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
cysteine-rich protein 1
Names
CRP-1
cysteine-rich intestinal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007763.3NP_031789.1  cysteine-rich protein 1

    See identical proteins and their annotated locations for NP_031789.1

    Status: VALIDATED

    Source sequence(s)
    AK008269, BX511593, DT908028
    Consensus CDS
    CCDS26205.1
    UniProtKB/Swiss-Prot
    P63254, Q3THF0
    Related
    ENSMUSP00000006523.8, ENSMUST00000006523.12
    Conserved Domains (1) summary
    cd09478
    Location:457
    LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    113115632..113117499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)